An amino acid-derived ABCBA-type antifouling biohybrid with multi-stimuli responsivity and contaminant removal capability

Abstract

A multi-stimuli (pH/thermo/redox)-responsive amphiphilic poly(cysteine methacrylamide)-block-poly(N,N-dimethylaminoethyl methacrylate)-block-polybutadiene-block-poly(N,N-dimethylaminoethyl methacrylate)-block-poly(cysteine methacrylamide) (PCysMAM-b-PDMAEMA-b-PB-b-PDMAEMA-b-PCysMAM) pentablock copolymer biohybrids, based on hydrophobic PB, ampholytic redox responsive PCysMAM and dual (pH and temperature) stimuli responsive PDMAEMA segments,...

Amino Acid‐Derived Smart and Functional Polymers for Biomedical Applications: Current Status and Future Perspectives

“…Kumar et al. [ 123 ] synthesized biocompatible amino acid based triple stimuli pH, temperature, and redox responsive amphiphilic poly(cysteine methacrylamide)‐ block ‐poly(2‐(dimethylamino)ethyl methacrylate)‐ block ‐polybutadiene‐ block ‐poly(2‐(dimethylamino)ethyl methacrylate)‐ block ‐poly(cysteine methacrylamide) (PCysMAM‐ b ‐PDMAEMA‐ b ‐PB‐ b ‐PDMAEMA‐ b ‐PCysMAM) pentablock copolymer biohybrids and investigate their stimuli‐responsive behavior, shown in Figure . Overall, the mechanism of smart behavior in amino acid‐derived smart polymers is highly dependent on the polymer's individual design, and it may be adapted to certain applications and stimuli.…”

“…Then, after Mohammad et al [122] again synthesized amino acid-based dual pH and temperature stimuli-responsive amphiphilic poly(histidine methacrylamide)block-hydroxyl-terminated polybutadiene-block-poly(histidine methacrylamide) (PHisMAM-b-PB-b-PHisMAM) triblock copolymer via Ni-Co alloy nanoparticles mediated RDRP and investigate their stimuli-responsive behavior in details, shown in Figure 9. Kumar et al [123]…”

“…[30,116] Because of their unique features and prospective uses in Reproduced with permission. [123] Copyright 2022, The Royal Society of Chemistry.…”

“…Figure 10. a) Chemical structure of the PCysMAM-b-PDMAEMA-b-PB-b-PDMAEMA-b-PCysMAM pentablock copolymer; b) FESEM image of the selfassembled amphiphilic pentablock copolymer; c) Cloud points measurement as a function of the CysMAM content to check temperature responsive properties; d) pH titration curve to check pH-responsive properties, showing the suggested charged states of the copolymer for the pH range 1.1 to 10.3; e) Investigation of the redox induced degradation of the crosslinked copolymer network by turbidity measurements to check redox responsive properties.Reproduced with permission [123]. Copyright 2022, The Royal Society of Chemistry.…”

Polymerization-induced self-assembly of (2-(4-vinylbenzyl)iso-indoline-1,3-dione) for the synthesis of hydrazine responsive block copolymer nanoparticles

“…This can be done by interchanging single and mixed solvent systems or by slowly introducing new solvents to the solution under very dilute conditions (less than 1 wt% polymer). [2][3][4][5][6][7][8][9][10][11][12] In other instances, postpolymerization modifications to the polymer are used to modulate self-assembly, but this can be difficult to implement on a large scale. 13 Self-assembled nanoparticles have unique properties that are relevant to a wide range of applications, such as drug delivery, biocatalysis, bio-imaging, and protein immobilization.…”