An alternatively spliced soluble TNF-α receptor is associated with metabolic disorders A replication study

Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes

“…The latter could be part of a protective response [ 47 ]. Tnfrsf1b and its interacting proteins were involved in the adipocytokine signaling pathway and increased TNF-alpha action would protect the organism from the damage by increasing HDL cholesterol in T2D patients [ 47 , 48 ]. The nonsynonymous SNV in Scg5 (chr3: 99641204:G->C) was predicted to be deleterious ( Fig 4D ) by SIFT [ 49 ].…”

Associations of inflammatory factors with glycaemic status among middle‐aged and older Chinese people

“…Subsequent studies demonstrated that DS‐sTNFR2 was inversely associated with fasting glucose and insulin resistance 30 . As indicated in those studies, 29–31 conventional ELISA systems, through measuring soluble sTNFR2, could not discriminate DS‐sTNFR2 from PC‐sTNFR2. Indeed, the plasma sTNFR2 in our study was measured with a method comparable with ELISA, which may explain, at least partially, the discrepancies of our study with others 23–28 .…”

Expression of TNFα membrane-bound receptors in the peripheral blood mononuclear cells (PMBC) in rheumatoid arthritis patients

“…Mediating components include Type-I and II membrane-bound TNF-receptors (TNFRs) [15] and the two biologically active forms of cytokine itself -soluble and membrane-bound [16,17]. Inhibiting components include soluble receptors generated by alternative splicing [18,19] or by proteolytic cleavage of the extracellular domain from the membrane-bound TNFRs [20,21]. Soluble receptors bind TNFa and can antagonize this cytokine by limiting its activity and binding overproduced TNFa, or can act as TNFa carriers [22][23][24][25].…”