An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain

Zhong, Xuemei; Schneider, Thomas J.; Cabral, D. S.; Donohoe, Terrence J.; Rothstein, Thomas L.

doi:10.1016/s0161-5890(01)00035-9

Cited by 46 publications

(52 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, an alternatively spliced form of FAIM mRNA generates a shorter protein that lacks 22 N-terminal amino acids (FAIM s ) (Zhong et al, 2001). Similar to the axonally localizing NMP35 studied here, overexpression of FAIM s increases neurite outgrowth (Sole et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Axonal transport of neural membrane protein 35 mRNA increases axon growth

Merianda

Vuppalanchi

Yoo

et al. 2013

Journal of Cell Science

View full text Add to dashboard Cite

SummaryMany neuronal mRNAs are transported from cell bodies into axons and dendrites. Localized translation of the mRNAs brings autonomy to these processes that can be vast distances from the cell body. For axons, these translational responses have been linked to growth and injury signaling, but there has been little information about local function of individual axonally synthesized proteins. In the present study, we show that axonal injury increases levels of the mRNA encoding neural membrane protein 35 (NMP35) in axons, with a commensurate decrease in the cell body levels of NMP35 mRNA. The 39 untranslated region (39UTR) of NMP35 is responsible for this localization into axons. Previous studies have shown that NMP35 protein supports cell survival by inhibiting Fas-ligand-mediated apoptosis; however, these investigations did not distinguish functions of the locally generated NMP35 protein. Using axonally targeted versus cell-body-restricted NMP35 constructs, we show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth.

show abstract

Section: Discussionmentioning

confidence: 99%

Axonal transport of neural membrane protein 35 mRNA increases axon growth

Merianda

Vuppalanchi

Yoo

et al. 2013

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…The Fas Apoptosis Inhibitory Protein (FAIM) was originally cloned by differential screening comparing cDNAs from CD95-sensitive and CD95-resistant B cells. 27,28 p35/Lifeguard has been implicated in neuronal protection against CD95L and it has been shown to be upregulated in a PI3K-dependent manner. 29,30 Also, phorbol esters have been shown to activate protein kinase C (PKC) and protect from CD95 apoptosis.…”

Section: The Cd95/cd95l Systemmentioning

confidence: 99%

Tyrosine phosphorylation and CD95: A FAScinating switch

Sancho‐Martinez¹,

Martín-Villalba²

2009

Cell Cycle

View full text Add to dashboard Cite

“…Later, an alternative spliced form containing 22 aa longer at the N terminus was reported and named FAIM long (FAIM L ) (Zhong et al, 2001). FAIM S is widely expressed, whereas FAIM L is almost exclusively expressed in the nervous system.…”

Section: Introductionmentioning

confidence: 99%