An alternative view of homocysteine

Dudman, Nicholas P.B.

doi:10.1016/s0140-6736(99)03383-8

Cited by 148 publications

(79 citation statements)

References 18 publications

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“…A 50% increase in tHcy was associated with a 60´9 mg L À1 increase in sVCAM-1 levels, which corresponds with a 6% increase in 7-year mortality risk [23]. This weak association between tHcy and sVCAM-1 does not provide strong evidence in favour of the hypothesis that tHcy is associated with an increased adherence of leukocytes to the endothelium, a hypothesis recently proposed by Dudman [42]. Our ®nding is in line with a recent study that demonstrated a signi®cant association between sVCAM-1 and carotid intimal medial thickness, a surrogate measurement of early atherosclerosis, but not between sVCAM-1 and tHcy [21].…”

Section: Discussionmentioning

confidence: 84%

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Becker

Hinsbergh

Kostense

et al. 2000

Eur J Clin Investigation

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Background Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was ®rstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade in¯ammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively. Secondly we investigated whether the presence of type 2 diabetes modi®es these associations.

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Section: Discussionmentioning

confidence: 84%

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Becker

Hinsbergh

Kostense

et al. 2000

Eur J Clin Investigation

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“…The relation of hyperinsulinemia and hyperhomocysteinemia in cardiovascular diseases has been demonstrated by several studies [11][12][13][14][15][16], but in women with PCOS whether plasma Hcy levels are associated with insulin resistance is still debated [8][9].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

2004

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Abstract. Hyperhomocysteinemia is a risk factor for atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in polycystic ovary syndrome (PCOS) patients than in healthy subjects. The aim of our study was to determine the relationship between plasma homocysteine level and insulin resistance in women with PCOS. Twenty-nine patients (age, 23.90 ± 5.86 years) and twenty-five healthy subjects (age, 25.24 ± 4.28 years) were involved in the study. Plasma levels of fasting insulin, glucose, homocysteine, FSH, and LH levels were measured. A statistically significant difference in plasma concentrations of HOMA index, homocysteine, basal insulin levels and LH/FSH ratios was observed between groups (P = 0.001, P = 0.001, P = 0.001, and P = 0.01, respectively). There was no relationship between Hcy and the other variables. In multiple logistic regression analysis, age, BMI and insulin resistance were not predictors of Hcy.

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“…UK Indian Asian men with evidence of CHD have higher levels of tHcy than European men with CHD [12]. However, the results only apply to men, the heterogeneity between South Asian subgroups was not taken into account [27] and the study did not allow for the possibility of increased tHcy after the coronary event [28,29]. The same study also indicates that the presence of the MTHFR T mutation does not contribute to the raised levels of tHcy in South Asians with CHD [15], although there was no attempt to look at differences between Hindus, Muslims and Sikhs.…”

Section: Main Findingsmentioning

confidence: 98%

Homocysteine levels in men and women of different ethnic and cultural background living in England

et al. 2002

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This population-based cross-sectional study in South London looks at the total homocysteine (tHcy) levels in groups of different ethnic background and the possible role of environmental factors and the 677C 0/T genetic polymorphism of the methylenetetrahydrofolate reductase (MTHFR). Fasting plasma tHcy was measured in 1392 men and women, age 40 Á/59 years; 475 were white, 465 of African origin (of whom 180 were West Africans and 280 Caribbeans) and 452 South Asian (of whom 222 were Hindus and 167 Muslims). The homozygous MTHFR TT variant had observed frequencies of 0.10 in whites, 0.01 in people of African origin and 0.02 in South Asians (P B/0.001). tHcy levels were 16% (95% CI 8 Á/26) higher amongst TT than CC. tHcy levels were 25% (21 Á/ 29) higher in men than women. Levels were significantly higher in South Asians than whites (8% [3 Á/13]). Vegetarians had higher levels than non-vegetarians (25% [18 Á/33]). These differences were present after adjustments for age, sex, smoking, body mass index (BMI), MTHFR 677C0/T polymorphism and socio-economic status. Compared with whites (10.0 [9.7 Á/10.3] mmol/l), and allowing for confounders, Hindus had significantly higher levels of tHcy (12.1 [11.6 Á/12.6] mmol/l). This difference was attenuated by the inclusion of vegetarianism in the model (11.3 [10.8 Á/11.9] mmol/l). In contrast Muslims had similar tHcy levels to whites while both West Africans and Caribbeans had slightly lower levels, though differences were not significant. The reported higher levels of tHcy in South Asians are due to high levels amongst Hindus only. They are in part accounted for by their vegetarianism. These differences in tHcy are large enough to be important contributors to the risk of vascular disease and may be preventable by simple targeted population strategies. #

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An alternative view of homocysteine

Cited by 148 publications

References 18 publications

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C‐reactive protein in type 2 diabetic and non‐diabetic subjects — The Hoorn Study

Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome

Homocysteine levels in men and women of different ethnic and cultural background living in England

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