Abstract:Aim: The aim of the present work is to report an alternative strategy to synthesis of (-)-Pyrenophorol. Methods: In this synthesis all intermediates and target compounds were fully characterized by different spectroscopic techniques such as 1 H NMR, 13 CNMR and EI-MS. Results and Discussion: The total synthesis of 16-membered C2-symmetric dilactone (-)-Pyrenophorol was prepared from (R, S)-di epoxide in 9 steps with good yields using Wittig olefination and Mitsunobu cyclization as key steps. Conclusion: A shor… Show more
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