An alternative strategy to construct uniform MOFs-Grafted silica core-shell composites as mixed-mode stationary phase for chromatography separation

Si, Tiantian; Wang, Shuai; Zhang, Haixia; Lu, Xiaofeng; Wang, Licheng; Liang, Xiaojing; Guo, Yong

doi:10.1016/j.aca.2021.338942

Cited by 12 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further investigate the chromatographic properties of PAM-Sil@ZIF-8(50 mg)/PAM, the effect of column temperature on the separation of five nucleosides/bases was conducted, as shown in Figure 6. It is reported that the effect of column temperature (15-35 • C) can be explained by the van't Hoff equation [23] (Equation ( 2)).…”

Section: Effect Of Column Temperaturementioning

confidence: 99%

ZIF-8 Assisted Polyacrylamide Functionalized Silica Core-Shell Stationary Phase for Hydrophilic Interaction Liquid Chromatography

Zhang

et al. 2023

Separations

Self Cite

View full text Add to dashboard Cite

A novel ZIF-8 assisted polyacrylamide functionalized silica polar stationary phase was prepared by a facile method of adding ZIF-8 nanoparticles and silica into polyacrylamide (PAM) aqueous solution, and then stirring the mixture until the solution was evaporated absolutely with the help of mechanical agitator. Interestingly, the prepared stationary phase (PAM-Sil@ZIF-8/PAM) showed favorable hydrophilicity, as demonstrated by good separation performance and strong retention ability toward several types of polar compounds, such as amino acids, saccharides, and alkaloids. In addition, PAM-Sil@ZIF-8(50 mg)/PAM showed better separation performance compared with amino-modified silica and Sil/PAM stationary phase due to the addition of ZIF-8. Furthermore, it was demonstrated that the addition of ZIF-8 improved the specific surface area and provided extra interaction sites for the stationary phase and analytes, which is beneficial for the separation of samples. In addition, the column efficiency can reach 7861.9 plates/m for colchicine. Moreover, it exhibited good stability and reproducibility under our operation conditions. In short, a novel stationary phase, which can be used for hydrophilic interaction liquid chromatography, was obtained and proved that the separation performance of polymer modifying silica stationary phase can be greatly improved by the addition of MOF nanoparticles.

show abstract

Section: Effect Of Column Temperaturementioning

confidence: 99%