An Allysine-Conjugatable Probe for Fluorogenically Imaging Fibrosis
Yilian Zhuang,
Tao Yin,
Jia Li
et al.
Abstract:Allysine, a pivotal biomarker in fibrogenesis, has prompted
the
development of various radioactive imaging probes. However, fluorogenic
probes targeting allysine remain largely unexplored. Herein, by leveraging
the equilibrium between the nonfluorescent spirocyclic and the fluorescent
zwitterionic forms of rhodamine-cyanine hybrid fluorophores, we systematically
fine-tuned the environmental sensitivity of this equilibrium toward
the development of fluorogenic probes for fibrosis. The trick lies
in modulating t… Show more
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