“…Instead we explored the final model for these two variables by adding them to the final model with only the participants of T2 and T4 (when those two variables were measured). Studies show that missing data in items of the CES-D scale appear to be ignorable, 40 80% of the 20 questions need to have logical value for a person to be assigned a CES-D composite score, 41 and multiple imputations are complex and do not increase precision in the estimated rate of change in the end point in linear mixed modelling. 42,43 Therefore, we chose to use zero imputation for the few items that were missing in the CES-D (n T0 = 26, n T1 = 29, n T2 = 26, n T3 = 24, n T4 = 40), HADS-A (n T0 = 0, n T1 = 5, n T2 = 10, n T3 = 4, n T4 = 6), LVQOL (n = 61) and AVL (n = 19) if there was at least an 80% completion.…”