An albumin-coated polyester arterial prosthesis made read to anastomose: in vivo evaluation in dogs

Guidoin, Robert; Marois, Yves; Rao, Tian-Jian; Torché, Dominique; Marceau, Daniel; Tenney, Barron; Duhamel, Raymond C.; Lebowitz, Elliot; Walcott, Cynthia

doi:10.1016/0267-6605(88)90016-9

Cited by 14 publications

(3 citation statements)

References 10 publications

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“…In contrast to Guidoin et al [8] who reported a rapid resorption of albumin in dogs the fast healing porcine model in our study showed traces of albumin for up to 12 weeks. Furthermore, a unique feature of albumin-coated grafts was an incomplete incorporation of the graft resulting in an easy peeling of the outer capsule [18].…”

Section: Discussioncontrasting

confidence: 54%

“…324 Following degradation of the sealing agent the knitted graft should regain the initial porosity thus allowing transinterstitial tissue ingrowth [26]. Technical problems mainly associated with the application and preservation of the sealant have only recently been overcome and the standardized fabrication of several coated grafts has been accomplished [8,13,21,22].…”

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confidence: 99%

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Evaluation of the healing of precoated vascular dacron prostheses

Hake¹,

Gabbert²,

Iversen³

et al. 1991

Langenbecks Arch Chir

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Knitted and woven Dacron grafts commercially coated with bovine collagen, gelatin and human albumin were implanted end-to-side between the infrarenal aorta and the bifurcation in 35 growing pigs. Grafts were explanted after 4, 8 and 12 weeks and compared to 6 uncoated knitted prostheses preclotted with blood that served as a control. Uncoated grafts rapidly developed a firmly attached neointima lined with endothelium. Compared with coated grafts the thrombus-free area of uncoated grafts was significantly larger (P less than 0.05). The slow resorption of albumin resulted in a delayed and incomplete neointimal healing and failing graft incorporation. Although the bovine collagen was only minimally cross-linked by formaldehyde, healing of the neointima was compromised in a thin woven graft that demonstrated peeling of the inner capsule even after 12 weeks. The identical collagen as well as bovine gelatin were quickly degraded in knitted grafts and both types showed transprosthetic infiltration at 4 weeks. All knitted grafts coated with either collagen or gelatin, however, were occluded after 8 and 12 weeks. Light microscopy revealed hyperplasia of smooth-muscle cells within the thickened distal anastomotic region. These results demonstrate that a timely return of porosity is mandatory for the development and maintenance of an intact neointima. Both the structure of the fabric as well as the method of preparing the coating are crucial variables to determine the rate of biodegradation.

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