An AIE active pyrene based fluorescent probe for selective sensing Hg2+ and imaging in live cells

Wu, Yaqin; Wen, Xiaoye; Fan, Zhefeng

doi:10.1016/j.saa.2019.117315

Cited by 47 publications

(11 citation statements)

References 51 publications

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“…The morphological changes upon complexation clearly demonstrated that the complex (4:Cd 2+ ) has distinct properties compared to the sensor (4). 49 Scheme…”

Section: Resultsmentioning

confidence: 99%

“…After the inclusion of Cd 2+ , the abrupt shrinkage of the area of the circular shape was noticed (diameter was reduced to 1.4 μm as shown in Figure d) along with the deformation of the regular shape. The morphological changes upon complexation clearly demonstrated that the complex ( 4:Cd 2+ ) has distinct properties compared to the sensor ( 4 ) …”

Section: Resultsmentioning

confidence: 99%

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Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Mondal

Dey

2021

ACS Omega

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A novel triazole-bridged coumarin−benzimidazole-conjugated fluorescence sensor (4) has been developed for selective detection of Cd 2+ over other competitive metal ions. The sensor exhibited quick "turn-on" responses upon interaction with a very low level of Cd 2+ (14 nM). The photophysical changes in the complexation of Cd 2+ with sensor 4 have been explained through the excited-state intramolecular proton transfer mechanism. The involvement of benzimidazole and triazole moieties in Cd 2+ binding was confirmed by different spectroscopic techniques such as UV−vis, Fourier transform infrared, nuclear magnetic resonance, and ESI mass. The diameter of the circular shape of the sensor decreased upon complexation with Cd 2+ , which was confirmed by field-emission scanning electron microscopy. Furthermore, the quantum chemical (density functional theory) calculation supported the mechanism of interactions and the mode of binding of 4 toward Cd 2+ . The sensor was more effective for finding Cd 2+ in two living cells, C6 (rat glial cell) and Hep G2 (human liver cell).

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“…The morphological changes upon complexation clearly demonstrated that the complex (4:Cd 2+ ) has distinct properties compared to the sensor (4). 49 Scheme…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Mondal

Dey

2021

ACS Omega

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“…The probe can be used for detection of Hg 2+ and found to be promising in environmental safety and biosystems (Figure 27 ). [80] …”

Section: Aie Active Molecule For Hg 2+ Ion Detectionmentioning

confidence: 99%

Aggregation Induced Emissive Luminogens for Sensing of Toxic Elements

et al. 2021

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The major findings in the growing field of aggregation induced emissive (AIE) active materials for the detection of environmental toxic pollutants have been summarized and discussed in this Review article. Owing to the underlying photophysical phenomenon, fluorescent AIE active molecules show more impact on sensing applications. The major focus in current research efforts is on the development of AIE active materials such as TPE based organic fluorescent molecules, metal organic framework, and polymers that can be employed for the detection of toxic pollutants such as CN − , NO 2 − , Hg 2+ , Cd 2+ , As 3+ , As 5+ , F − , Pb 2+ , Sb 3+ ions.

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“…Coordination chemistry has been employed for the recognition of Hg 2+ [51][52][53][54][55][56][57][58][59][60]. Structures containing Schiff base, sulfydryl, and imidazole groups show effectiveness for Hg 2+ binding.…”

Section: Mercury Ionsmentioning

confidence: 99%

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Zhong

Huang

et al. 2019

Molecules

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Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications.

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An AIE active pyrene based fluorescent probe for selective sensing Hg2+ and imaging in live cells

Cited by 47 publications

References 51 publications

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Aggregation Induced Emissive Luminogens for Sensing of Toxic Elements

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

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An AIE active pyrene based fluorescent probe for selective sensing Hg2+ and imaging in live cells

Cited by 47 publications

References 51 publications

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd2+ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd2+ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Aggregation Induced Emissive Luminogens for Sensing of Toxic Elements

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Contact Info

Product

Resources

About

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study

Strategy to Design a Flexible and Macromolecular Sensor to Bind Cd²⁺ Ions: A Complete Photophysical Analysis and Bio-Imaging Study