An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation

Zhang, Xuemei; Liu, Qing; Hu, Junhua; Xu, Ling; Tan, Wen

doi:10.1016/j.apsb.2013.12.010

Cited by 16 publications

(6 citation statements)

References 32 publications

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“…Many techniques for B. odoriphaga control have been investigated, including entomopathogenic nematodes [9][10][11], colored plates, and other methods that do not involve chemical pesticides [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Non-Lethal High-Temperature Stress on Bradysia odoriphaga (Diptera: Sciaridae) Larval Development and Offspring

Shi

Zhang

et al. 2020

Insects

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Throughout China, the dipteran pest Bradysia odoriphaga significantly reduces Chinese chive production; therefore, identifying conditions that influence its growth and development is crucial for developing ecological regulation strategies. In this study, different non-lethal high temperatures and treatment durations were used to stress the third-instar larvae of B. odoriphaga, and the effects of this treatment on their growth and offspring were recorded and analyzed. The results showed that the average larval mortality increased with increased temperature and prolonged exposure times. After stress treatment at 40 °C for 2 h, 100% of larvae died within 5 days, which was not significantly different from the 5-day average larval mortality (90.66%) after stress at 37 °C for 4 h, but significantly higher than the 5-day average larval mortality (72.00%) after stress at 40 °C for 1 h. After 5 days, all still-living larvae could pupate, and there was no significant difference in average pupal period after pupation. However, the eclosion rate of subsequent pupae decreased with increased temperature and prolonged exposure times, and were only 43.00% and 42.73% after larvae were stressed at 37 °C for 4 h and 40 °C for 1 h, respectively. After eclosion into adults, there was no significant difference in the lifespan of unmated female adults, while the lifespan of unmated male adults was significantly reduced to 1.67 d and 2 d after larvae were stressed at 37 °C for 4 h and 40 °C for 1 h, respectively. However, there was no significant difference in male and female adult longevity after mating. There was no significant difference in oviposition or egg hatchability. This indicates that non-lethal high temperature at 37 °C for 4 h can hinder development and allow control of B. odoriphaga. There is great potential for non-lethal high temperature to be applied in the field to control agricultural pests.

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Section: Introductionmentioning

confidence: 99%

Effects of Non-Lethal High-Temperature Stress on Bradysia odoriphaga (Diptera: Sciaridae) Larval Development and Offspring

Shi

Zhang

et al. 2020

Insects

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“…41,42 The NGI is a high-performance cascade impactor for classifying aerosol particle into size fractions for testing inhaled drug delivery devices such as nebulizers. 43 Moreover, Spraytec is one of the most popular laser diffraction devices specically designed to address the unique requirements of aerosol and spray droplet characterization and provides real-time and accurate droplet measurement. [44][45][46] Consistent with the results of DR, TDD, and TED, we observed that Pari Boy SX (red) produced the lowest aerosol particle size of RIS among these ve nebulizers, suggested by the values of D 50 and MMAD.…”

Section: Discussionmentioning

confidence: 99%

Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers

Zhang

Cheng

et al. 2019

RSC Adv.

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“… 1 Asthma may also be classified as atopic (extrinsic) or nonatopic (intrinsic), where atopy refers to a predisposition toward developing type 1 hypersensitivity reactions. 2 , 3 Asthma is the clinical condition that may occur in adult and pediatric patients. For some children with asthma, their first asthmatic experience can be frightening – heavy wheezing, a tight chest, and shortness of breath can quickly catch their active, young bodies off-guard.…”

Section: Introductionmentioning

confidence: 99%

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

Chen¹,

Liang²,

Cen³

et al. 2015

DDDT

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The purpose of the present study was to develop oral dispersible tablets containing prednisolone (PDS)-loaded chitosan nanoparticles using microcrystalline cellulose (MCC 101), lactose, and croscarmellose sodium (CCS). The PDS-loaded chitosan nanoparticles were formulated by ionotropic external gelation technique in order to enhance the solubility of PDS in salivary pH. Prepared nanoparticles were used for the development of oral fast disintegrating tablets by direct compression method. The prepared tablets were evaluated for disintegration time (DT), in vitro drug release (DR), thickness, weight variation, drug content uniformity, friability, and hardness. The effect of concentrations of the dependent variables (MCC, lactose, CCS) on DT and in vitro DR was studied. Fast disintegrating tablets of PDS can be prepared by using MCC, CCS, and lactose with enhanced solubility of PDS. The minimum DT was found to be 15 seconds, and the maximum DR within 30 minutes was 98.50%. All independent variables selected for the study were statistically significant. Oral fast disintegrating tablets containing PDS nanoparticles could be the better choice for the pediatric patients that would result in better patient compliance. From this study, it can be concluded that fast disintegrating tablets could be a potential drug delivery technology for the management of asthma in pediatrics.

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An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation

Cited by 16 publications

References 32 publications

Effects of Non-Lethal High-Temperature Stress on Bradysia odoriphaga (Diptera: Sciaridae) Larval Development and Offspring

Effects of Non-Lethal High-Temperature Stress on Bradysia odoriphaga (Diptera: Sciaridae) Larval Development and Offspring

Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

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