Background: Cardiovascular disease (CVD) is a global health issue. Literature has shown that primary care nurse-led cardiovascular disease clinics improve cardiac patient outcomes. These clinics improve the level of services provided, increase patient satisfaction, and decrease the mortality rate.Aim: This literature review aims to identify the roles and responsibilities of nurses working in CVD nurse-led clinics and to identify the outcomes of these nurse-led clinics.Method: Whittemore and Knafl’s framework guided this integrative review. Seventeen studies published between 2017 and 2022 were included in the review. The Mixed-Method Appraisal Tool was used to assess the quality of the studies.Results: Three themes emerge in this literature review: roles and responsibilities of nurse-led CVD clinics, the impact of nurse-led CVD clinics, and the qualifications of nurses working in these clinics.Conclusions: This integrative review identifies a framework for the roles and responsibilities of nurse-led CVD clinics and highlights the positive patient outcomes. This framework will help CVD nurse-led clinics to meet the needs of patients and achieve a high level of patient satisfaction.