An advanced near real dynamic<i>in vitro</i>human stomach system to study gastric digestion and emptying of beef stew and cooked rice

Wang, Jingjing; Wu, Peng; Liu, Minghui; Liao, Zhenkai; Wang, Yong; Dong, Zhizhong; Chen, Xiao

doi:10.1039/c8fo02586j

Cited by 92 publications

(58 citation statements)

References 37 publications

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“…Therefore, RD‐IV‐HSM not only focuses on the simulation of biochemical environments (i.e. pH, enzymes, salts, and transit time) and in vivo physical movements, but also considers the effects of morphological and geometrical details of the real human stomach or intestine on digestive behaviors 39 . It is worth noting that RD‐IV‐HSM has been used to investigate the changes of food constituents, the distribution of the semisolid food and the gastric emptying behaviors during digestion.…”

Section: Discussionmentioning

confidence: 99%

In vitro and In vivo digestion comparison of bee pollen with or without wall‐disruption

Qiao

Xiao

et al. 2020

J Sci Food Agric

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BACKGROUND Bee pollen is considered as a treasure trove of human and animal nutrients as a result of its extensive nutritional and therapeutic properties. However, the sophisticated pollen wall can largely limit the digestibility and bioavailability of these nutrients. RESULTS An ultrasonication and high shear technique was used to break the walls of five species of bee pollen, including rape bee pollen, lotus bee pollen, camellia bee pollen, wuweizi bee pollen and apricot bee pollen. We compared the digestibilities of bee pollen with or without wall‐disruption. After in vitro and in vivo digestion, unbroken bee pollen grains were still intact and the fragments of wall‐disrupted bee pollen still remained as fragments. Mouse in vivo digestion results suggested that the wall‐disrupted bee pollen was more easily emptied from the gastrointestinal tract than unbroken bee pollen. After dynamic in vitro digestion, the digestibilities of protein and crude fat in wall‐disrupted bee pollen significantly increased to more than 80%; similarly, the release rates of amino acids and reducing sugars in all wall‐disrupted samples were almost 1.5 and 2 times as much as those of unbroken samples. CONCLUSION Based on the results obtained in the present study, we strongly recommend that bee pollen should be wall‐disrupted. © 2020 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

In vitro and In vivo digestion comparison of bee pollen with or without wall‐disruption

Qiao

Xiao

et al. 2020

J Sci Food Agric

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“…However, other more recent but less validated dynamic models have been published in recent years that are working towards the development of more realistic GI digestion simulation. For instance, the in vitro mechanical gastric system (IMGS), 130 the new dynamic in vitro human stomach system (DIVHS), 131 the gastric simulation model (GSM) 132 and the artificial gastric digestive system (AGDS). 66 Their general features are described in Table 5 for comparison.…”

Section: Reviewmentioning

confidence: 99%

Simulating human digestion: developing our knowledge to create healthier and more sustainable foods

2020

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“…A final application of the sensor material was used to gauge its suitability for monitoring large scale soft tissue deformation, of the type that would be seen with mammalian organs. This was achieved by laminating the sensor to an anatomically realistic, silicone stomach model, from an in vitro human digestion simulation system [54]. Sensor position is illustrated in Figure A2 from Appendix A and is located on the anterior body wall.…”

Section: Resultsmentioning

confidence: 99%

“…The stomach was compressed with rollers, simulating gastric motility. The model system was previously described by Wang et al [54] A short video of the process is available in the Supplementary Material.…”

Section: Methodsmentioning

confidence: 99%

“…Durability during large strain (50%) repetitive motion was established via testing over 10,000 tensile strain cycles, while body motion monitoring was demonstrated by fixing planar sensors to paper elbow and knee bands, with tissue deformation examined via fixing a sensor to the silicone stomach of an in vitro model of human digestion. [54] The latter, by monitoring the peristaltic contractions that drive gastric motility, opens the possibility of enhancing in-demand in vitro models of gastric digestion [12,13]. Additionally, the effects of temperature and humidity upon sensor performance were examined.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Practical and Durable Flexible Strain Sensors Based on Conductive Carbon Black and Silicone Blends for Large Scale Motion Monitoring Applications

Xia

Zhang

et al. 2019

Sensors

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Presented is a flexible capacitive strain sensor, based on the low cost materials silicone (PDMS) and carbon black (CB), that was fabricated by casting and curing of successive silicone layers—a central PDMS dielectric layer bounded by PDMS/CB blend electrodes and packaged by exterior PDMS films. It was effectively characterized for large flexion-angle motion wearable applications, with strain sensing properties assessed over large strains (50%) and variations in temperature and humidity. Additionally, suitability for monitoring large tissue deformation was established by integration with an in vitro digestive model. The capacitive gauge factor was approximately constant at 0.86 over these conditions for the linear strain range (3 to 47%). Durability was established from consistent relative capacitance changes over 10,000 strain cycles, with varying strain frequency and elongation up to 50%. Wearability and high flexion angle human motion detection were demonstrated by integration with an elbow band, with clear detection of motion ranges up 90°. The device’s simple structure and fabrication method, low-cost materials and robust performance, offer promise for expanding the availability of wearable sensor systems.

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An advanced near real dynamicin vitrohuman stomach system to study gastric digestion and emptying of beef stew and cooked rice

Abstract: A near real dynamic in vitro human stomach (new DIVHS) system has recently been advanced in this study, based on the previous rope-driven in vitro human stomach model (RD-IV-HSM).

Cited by 92 publications

References 37 publications

In vitro and In vivo digestion comparison of bee pollen with or without wall‐disruption

In vitro and In vivo digestion comparison of bee pollen with or without wall‐disruption

Simulating human digestion: developing our knowledge to create healthier and more sustainable foods

Practical and Durable Flexible Strain Sensors Based on Conductive Carbon Black and Silicone Blends for Large Scale Motion Monitoring Applications

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