An Adult Case of Multiple Squamous Papillomas of the Trachea Associated with Human Papilloma Virus Type 6

Shibuya, Hideki; Kutomi, Tomoko; Kujime, Kosei; Hara, Kei; Hisada, Tetsuya

doi:10.2169/internalmedicine.47.1239

Cited by 10 publications

(10 citation statements)

References 19 publications

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“…Two different types usually present distinct clinical courses. RRP arising in the trachea without a laryngeal lesion has been occasionally reported in adult cases (2). Here we report our experience of diagnosis and treatment in a juvenile case.…”

Section: Introductionmentioning

confidence: 82%

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Xue

Wang

2010

Intern. Med.

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Recurrent respiratory papillomatosis (RRP) is an infrequent benign neoplasm commonly involving the upper respiratory tract with laryngeal predilection. The diagnosis and treatment of this disease are challenging due to its nonspecific clinical presentations and recurrent nature. We report here a rare juvenile case of RRP arising in the trachea without laryngeal lesions. Our experiences indicate that a high awareness of RRP and proper consideration in the right clinical context are prerequisites for early diagnosis, and a combination of multiple treatment modalities should be considered as a feasible treatment regimen.

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Section: Introductionmentioning

confidence: 82%

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Xue

Wang

2010

Intern. Med.

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“…In total, ~100 different types of HPV have been identified, each associated with different malignant potentials and symptom severities. HPV 6 and 11 are the most commonly identified types in cases of solitary tracheobronchial papilloma and are associated with a low risk of carcinomatous transformation (1,13). In addition, HPV types 16 and 18, occasionally in combination with types 31, 33 or 35, are associated with a higher risk of carcinomatous transformation (13).…”

Section: Discussionmentioning

confidence: 99%

“…It most frequently occurs in children or adolescents (1). Solitary papilloma is extremely rare and its occurrence in the trachea is even rarer, accounting for <0.5% of all lung tumors (2).…”

Section: Introductionmentioning

confidence: 99%

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Feng¹,

Wang²,

Chen³

et al. 2015

Oncology Letters

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Abstract. The present study described a rare case of malignant conversion of a solitary papilloma in the trachea, in addition to reviewing the current literature. A 54-year-old male presented with a cough, sputum and dyspnea. Chest computed tomography revealed a mediastinal soft-tissue mass in the trachea. A tumor biopsy, performed using a flexible bronchofiberscope, identified a squamous cell papilloma with moderate to severe atypical hyperplasia, as well as the formation of squamous cell carcinoma. Polymerase chain reaction analysis did not detect presence of human papilloma virus in the tumor. The patient was subsequently treated with radiotherapy and no evidence of recurrence was observed during a two-year follow-up period. To the best of our knowledge, this is the first study to describe the malignant conversion of a solitary papilloma in the trachea, which was subsequently treated with radiotherapy.

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“…Although benign papillomas are caused by the low-risk group HPV 6 and 11, HPV 16 and 18 usually result in cervical cancers or squamous cell cancer of the oral pharynx. HPV association with lung cancer is an unsettled issue; however,8 involvement of the lower airway by papillomas is reported only in a few cases 9. Known host factors10 affecting disease progression include tobacco smoking, coinfection with other sexually transmitted diseases such as HIV, hepatitis C or long-term immunosuppression in patients who are either on immunosuppressants for solid organ transplant or autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Suppression of respiratory papillomatosis with malignant transformation by erlotinib in a kidney transplant recipient

et al. 2013

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A 52-year-old non-smoker and renal transplant recipient developed an incessant cough. A CT scan of the thorax revealed ill-defined hazy opacities in the right upper lung. He was diagnosed with non-tuberculosis Mycobacterium chelonae/abscessus infection based on sputum culture results. A trial of antibiotics initially resulted in some clinical improvement. A subsequent CT of the thorax documented worsening of the lesions in the right lung and new lesions on the left. An intratracheal growth was noted. Bronchoscopy with biopsy of the tracheal lesions documented respiratory papillomatosis with transformation to squamous cell cancer. Test for high-risk human papilloma virus was positive. Video-assisted thoracoscopic surgery biopsy with wedge resection of the left lower lobe revealed metastatic squamous cell lung cancer. He was treated with one ablation followed by four cycles of chemotherapy. He has been maintained on erlotinib ever since. There has been no recurrence of the cough or papillomas.

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An Adult Case of Multiple Squamous Papillomas of the Trachea Associated with Human Papilloma Virus Type 6

Abstract: Abstract

Cited by 10 publications

References 19 publications

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Recurrent Respiratory Papillomatosis Arising in Trachea not Affecting Larynx

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Suppression of respiratory papillomatosis with malignant transformation by erlotinib in a kidney transplant recipient

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