An Adrenergic Neurone Blocking Action of Dimethylphenylpiperazinium

Wilson, A. B.

doi:10.1111/j.2042-7158.1962.tb11162.x

Cited by 20 publications

(13 citation statements)

References 4 publications

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“…This effect, not shared by ganglion blocking agents, can only be explained by an action distal to the ganglia. Wilson (1962) made similar observations on the guinea-pig intestine and reached a similar conclusion. Sympathetic nerve stimulation also reduced contractions produced by histamine (in the presence of hyoscine) and by acetylcholine.…”

Section: Discussionsupporting

confidence: 72%

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Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action

Gershon¹

1967

The Journal of Physiology

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SUMMARY1. The mechanism of sympathetic nervous inhibition of gastrointestinal movement was investigated in order to determine whether the primary action of sympathetic nerve stimulation was on ganglia or on the smooth muscle itself.2. The effect of sympathetic nerve stimulation did not resemble the effect of ganglionic blockade or that of removing all nervous tone with tetrodotoxin.3. The same frequency of sympathetic nerve stimulation to the rabbit jejunum which inhibited the myogenic spontaneous activity blocked excitatory responses to transmural post-ganglionic cholinergic nerve stimulation and antagonized contractions in response to drugs acting directly on the smooth muscle.4. Acetylcholine output was measured as an indicator of post-ganglionic nervous activity. In contrast to hexamethonium, stimulation of sympathetic nerves at frequencies of stimulation sufficient to relax the muscle did not reduce the output of acetylcholine.5. Vagus nerves and sympathetic nerves to the guinea-pig stomach were stimulated individually and simultaneously in the presence of hyoscine. The relaxant responses to stimulation of the two nerves summated when they were stimulated simultaneously, indicating that the transganglionic vagal pathway was not blocked.6. It is concluded that the effect of sympathetic nerve stimulation is due to the direct action of the released noradrenaline on the smooth muscle.

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Section: Discussionsupporting

confidence: 72%

“…or by hexamethonium (5 X 10-5 g/ml.) (Wilson, 1962), although hexamethonium occasionally increased the magnitude of the spontaneous contractions of the rabbit jejunum ( Fig. 2a and b) (Birmingham & Wilson, 1965).…”

Section: Resultsmentioning

confidence: 99%

Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action

Gershon¹

1967

The Journal of Physiology

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“…When a range of concentrations of each drug was tested on separate preparations from the same rabbit, the rates of progression and the final amounts of block produced were almost equal with bretylium (2 x 10-6), guanethidine (1 x 10-6) and DMPP (4 x 10-7). We have confirmed the reports of Bentley (1962) for the rabbit and Wilson (1962) for the guinea-pig, that in the small intestine the inhibitory effects of periarterial sympathetic nerve stimulation are blocked by DMPP. What is the site and mechanism of this blocking action ?…”

supporting

confidence: 79%

An Analysis of the Blocking Action of Dimethylphenylpiperazinium Iodide on the Inhibition of Isolated Small Intestine Produced by Stimulation of the Sympathetic Nerves

Birmingham

Wilson

1965

British Journal of Pharmacology and Chemotherapy

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“…Closely related to this interpretation is the possibility that acetylcholine, in a persistently high concentration, exerts an adrenergic neurone blocking action (Rand & Wilson, 1967). However, it is thought that the inhibitory action of acetylcholine on noradrenaline release is nicotinic, since it is demonstrable in the presence of atropine (for references, see Introduction), and is also exhibited by the nicotinic stimulants nicotine and dimethylphenylpiperazinium (Bentley, 1962;Wilson, 1962;Birmingham & Wilson, 1965 ;Rand & Wilson, 1967). Atropine increased the concentrations of acetylcholine or methacholine which were required to reduce responses to sympathetic nerve stimulation by a factor of about 100.…”

Section: Discussionmentioning

confidence: 99%

The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery

Rand

Varma

1970

British J Pharmacology

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Summary1. The effects of infusions of the cholinomimetic drugs acetylcholine, methacholine, muscarine, carbachol, arecoline and pilocarpine were examined on vasoconstrictor responses of the perfused rabbit ear artery to sympathetic nerve stimulation and to injections of noradrenaline.2. The first effect of very low concentrations of acetylcholine or muscarine was a slight enhancement of responses to sympathetic nerve stimulation, but when higher concentrations of acetylcholine, methacholine, muscarine, carbachol and arecoline were infused, these vasoconstrictor responses were decreased.With still higher concentrations the responses tended to increase in size during the infusion. After stopping an infusion, the depressed vasoconstrictor responses rapidly recovered and became enhanced. 3. Infusions of pilocarpine in a wide range of concentrations generally caused enhancement of responses. 4. The depressant effects of cholinomimetic drugs on the responses to sympathetic nerve stimulation were antagonized by atropine. Larger concentrations of the drugs overcame the blockade by atropine. 5. The effects of acetylcholine, methacholine and muscarine on the responses to sympathetic nerve stimulation were more pronounced at low than at high frequencies of stimulation. 6. Vasoconstrictor responses to injected noradrenaline were enhanced by acetylcholine or methacholine, whereas responses to sympathetic nerve stimulation were decreased by the same concentrations of these choline esters. 7. It is suggested that cholinomimetic drugs may act on receptor sites associated with the adrenergic terminal axon and that they may facilitate or impair the release of noradrenaline and impair noradrenaline uptake.

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An Adrenergic Neurone Blocking Action of Dimethylphenylpiperazinium

Cited by 20 publications

References 4 publications

Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action

Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action

An Analysis of the Blocking Action of Dimethylphenylpiperazinium Iodide on the Inhibition of Isolated Small Intestine Produced by Stimulation of the Sympathetic Nerves

The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery

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