An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Borriello, Francesco; Poli, Valentina; Shrock, Ellen; Spreafico, Roberto; Liu, Xin; Pishesha, Novalia; Carpenet, Claire; Chou, Janet; Gioia, Marco Di; McGrath, Marisa E.; Dillen, Carly; Barrett, Nora A.; Lacanfora, Lucrezia; Franco, Marcella E.; Marongiu, Laura; Iwakura, Yoichiro; Pucci, Ferdinando; Kruppa, Michael; Ma, Zuchao; Lowman, Douglas W.; Ensley, Harry E.; Nanishi, Etsuro; Saito, Yoshine; O’Meara, Timothy R.; Seo, Hyuk-Soo; Dhe‐Paganon, Sirano; Dowling, David J.; Frieman, Matthew B.; Elledge, Stephen J.; Levy, Ofer; Irvine, Darrell J.; Ploegh, Hidde L.; Williams, David L.; Zanoni, Ivan

doi:10.1016/j.cell.2022.01.009

Cited by 57 publications

(35 citation statements)

References 78 publications

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“…This mode of action of glucan may counteract the effect of lactate in promoting HMGB1 release during SARS-CoV-2 infection ( 13 ). Importantly, a recent study has shown that glucans and mannans can be used as adjuvants to enhance the magnitude and durability of COVID-19 vaccines ( 201 – 203 ).…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

et al. 2022

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Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

et al. 2022

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“…In response of fungal infection, CLRs will be activated by sensing cell wall polysaccharides, leading to potent cytokine production and subsequent development of humoral and cellular immune response. Polysaccharides β-glucans and mannans can activate CLRs Dectin-1 and Dectin-2, respectively, while these CLRs are not the sole receptors for the defined polysaccharides, depending on their source and physical properties (such as soluble or particulate) [ 156 , 157 ]. Thus, the studies on polysaccharides-based formulations in nanoscale for mRNA delivery would provide new understandings on their receptor signalling and associated vaccine immunological activity, which potentially offers guidelines in engineering advanced nano-mRNA systems.…”

Section: Recent Advanced Nanoformulation-mediated Mrna Immunotherapie...mentioning

confidence: 99%

Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

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et al. 2023

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“…Because optimal programming leads to the generation of long-lasting memory CD8 + T cells ( 224 , 225 ) and contributes to fungal vaccine immunity ( 8 ), we reason that a potent fungal vaccination can “license” dendritic cells for CD8 + T-cell priming independent of CD4 + T-cell help. Fungi are decorated, including some secretory, with several potential PAMPs that can bolster the dendritic cell activation and functions ( 226 – 228 ). Therefore, the CD8 + T-cell memory imprinting and memory homeostasis following fungal vaccination can be independent of CD4 + T-cell help ( 16 , 169 ).…”

Section: Cd4 + T-cell Help For Antifungal Cd8 ...mentioning

confidence: 99%

T cell responses to control fungal infection in an immunological memory lens

2022

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In recent years, fungal vaccine research emanated significant findings in the field of antifungal T-cell immunity. The generation of effector T cells is essential to combat many mucosal and systemic fungal infections. The development of antifungal memory T cells is integral for controlling or preventing fungal infections, and understanding the factors, regulators, and modifiers that dictate the generation of such T cells is necessary. Despite the deficiency in the clear understanding of antifungal memory T-cell longevity and attributes, in this review, we will compile some of the existing literature on antifungal T-cell immunity in the context of memory T-cell development against fungal infections.

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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Cited by 57 publications

References 78 publications

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

T cell responses to control fungal infection in an immunological memory lens

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