One strategy for distinguishing smooth structures on closed 4-manifolds is to produce a knot K in S 3 that is slice in one smooth filling W of S 3 but not slice in some homeomorphic smooth filling W . In this paper we explore how 0-surgery homeomorphisms can be used to potentially construct exotic pairs of this form. In order to systematically generate a plethora of candidates for exotic pairs, we give a fully general construction of pairs of knots with the same zero surgeries. By computer experimentation, we find 5 topologically slice knots such that, if any of them were slice, we would obtain an exotic four-sphere. We also investigate the possibility of constructing exotic smooth structures on # n CP 2 in a similar fashion.