An Address System in the Vasculature of Normal Tissues and Tumors

Ruoslahti, Erkki; Rajotte, Daniel

doi:10.1146/annurev.immunol.18.1.813

Cited by 209 publications

(134 citation statements)

References 71 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…In vivo proteomic approaches have revealed a striking array of vascular bed-specific phenotypes (reviewed in Rajotte 2000 andSimonson andSchnitzer 2007). For example, antibody and subfractionation strategies have been used to generate monoclonal antibodies that specifically target the caveolae in one vascular bed or another (McIntosh et al 2002).…”

Section: Endothelial Cell Phenotypesmentioning

confidence: 99%

Endothelial Cell Heterogeneity

Aird

2011

Cold Spring Harbor Perspectives in Medicine

592

459

View full text Add to dashboard Cite

Section: Endothelial Cell Phenotypesmentioning

confidence: 99%

Endothelial Cell Heterogeneity

Aird

2011

Cold Spring Harbor Perspectives in Medicine

592

459

View full text Add to dashboard Cite

“…A new approach is therefore to develop agents that induce apoptosis in androgen-independent prostate cancer cells, in a proliferation-independent manner. Several of these agents are under preclinical development, and include PSA-activated prodrugs 80,81 and targeted anti-angiogenic agents 82 . Several are also in early clinical trials.…”

Section: Future Directionsmentioning

confidence: 99%

A history of prostate cancer treatment

2002

View full text Add to dashboard Cite

The increased incidence of prostate cancer has led to remarkable changes in diagnosis and treatment over the past century. What were the first ways in which prostate cancer was treated, and how did these evolve into the variety of therapeutic strategies from which patients have to choose today?In 1853, J. Adams, a surgeon at The London Hospital, described the first case of prostate cancer, which he discovered by histological examination 1 . Adams noted in his report that this condition was "a very rare disease". Remarkably, 150 years later, prostate cancer has become a significant health problem. In the United States, it is the most commonly diagnosed cancer in men, with 180,000 new cases and about 31,000 deaths occurring annually 2 . This dramatic increase in the number of prostate cancer cases can be attributed to several causes. First, prostate cancer was not differentiated from other types of urinary obstruction until the early 1900s. Second, the incidence of prostate cancer increases more rapidly with age than any other cancer type 2 . The number of cases has risen as the average life expectancy has increased over the past century. Third, the increased incidence seems to be, in some way, related to the 'Western' lifestyle: the incidence of clinical prostate cancer is significantly lower in Asian populations, compared with Western populations 3 , and it

show abstract

“…Alternatively, the angiogenic response of the endothelium to VEGF may be host organdependent. Indeed, endothelial cells have organspecific phenotypes and specialized properties Ruoslahti and Rajotte, 2000). Finally, the metabolic organ microenvironment and its interaction with neoplastic cells may modulate the VEGF response in vivo.…”

Section: Vegf In Orthotopic Pancreatic Tumormentioning

confidence: 99%

Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation

Tsuzuki

Carreira

Bockhorn

et al. 2001

Laboratory Investigation

102

View full text Add to dashboard Cite

SUMMARY:Pancreatic cancer has a poor prognosis, and treatment strategies based on preclinical research have not succeeded in significantly extending patient survival. This failure likely stems from the general lack of information on pancreatic tumor physiology, attributable to the difficulties in developing relevant, orthotopic models that accurately reflect pancreatic cancer in the clinic. To overcome this limitation, we developed abdominal wall windows suitable for intravital microscopy that allowed us to monitor angiogenesis and microvascular function noninvasively during tumor growth in vivo. We used two complementary tumor models in mice: orthotopic (human ductal pancreatic adenocarcinoma, PANC-1, grown in the pancreas), and ectopic (PANC-1 grown in the abdominal wall). We found that orthotopic PANC-1 tumors grew faster than the ectopic tumors and exhibited metastatic spread in the late stage similar to advanced pancreatic cancer in the clinic. Orthotopic PANC-1 tumors expressed vascular endothelial growth factor (VEGF) 121 and VEGF 165 , contained higher levels of tumor cell-derived VEGF protein, and maintained vascular density and hyperpermeability during exponential tumor growth. Orthotopic PANC-1 tumors showed lower leukocyte-endothelial interactions in the early stage of growth. In addition, both VEGF 121 and VEGF 165 promoted the growth of PANC-1 cells in vitro. Finally, Anti-VEGF neutralizing antibody inhibited angiogenesis and tumor growth of PANC-1 tumors in both sites. We conclude that the orthotopic pancreas microenvironment enhances VEGF expression, which stimulates growth of PANC-1 tumors (compared with ectopic tumors). The mechanism is autocrine and/or paracrine and also is involved in the maintenance of blood vessels. This comparative system of orthotopic and ectopic pancreatic cancer will provide the rigorous understanding of pancreatic tumor pathophysiology needed for development of novel therapeutic strategies. (Lab Invest 2001,

show abstract

An Address System in the Vasculature of Normal Tissues and Tumors

Cited by 209 publications

References 71 publications

Endothelial Cell Heterogeneity

Endothelial Cell Heterogeneity

A history of prostate cancer treatment

Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation

Contact Info

Product

Resources

About