An Additive-Free Model for Tau Self-Assembly

Al-Hilaly, Youssra K.; Marshall, Karen E.; Lutter, Liisa; Biasetti, Luca; Mengham, Kurtis; Harrington, Charles R.; Xue, Wei‐Feng; Serpell, Louise C.

doi:10.1007/978-1-0716-2597-2_12

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Under pathological conditions, tau phosphorylation sites may reach saturation, and the highly phosphorylated tau protein in the brain of AD patients may lead to its configuration change and loss of tubulin polymerization ability, resulting in impaired microtubule function [ 31 , 32 ]. A high level of intracellular tau is involved in tau-tau interactions that may form insoluble PHFs and straight filaments (SFs), resulting in the formation of intracranial fibrous deposits, namely NFTs [ 33 ]. NFTs can reduce the number of synapses, produce neurotoxicity, and cause cellular dysfunction [ 34 ].…”

Section: Hypothesis Of Pathogenesis Of Admentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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Alzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD. Resveratrol, curcumin, kaempferol and other Chinese herbal medicine components can significantly inhibit the neuroinflammation of AD in vivo and in vitro, and are candidates for the treatment of AD. Acupuncture can alleviate the memory and cognitive impairment of AD by improving neuroinflammation, synaptic plasticity, nerve cell apoptosis and reducing the production and aggregation of amyloid β protein (Aβ) in the brain. It has the characteristics of early, safe, effective and benign bidirectional adjustment. The purpose of this paper is to provide a basis for improving the clinical strategies of TCM for the treatment of AD. Graphical Abstract

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Section: Hypothesis Of Pathogenesis Of Admentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies

Chitty,

Kuliga,

Xue

2024

Biochemical Society Transactions

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Recent developments in atomic force microscopy (AFM) image analysis have made three-dimensional (3D) structural reconstruction of individual particles observed on 2D AFM height images a reality. Here, we review the emerging contact point reconstruction AFM (CPR-AFM) methodology and its application in 3D reconstruction of individual helical amyloid filaments in the context of the challenges presented by the structural analysis of highly polymorphous and heterogeneous amyloid protein structures. How individual particle-level structural analysis can contribute to resolving the amyloid polymorph structure–function relationships, the environmental triggers leading to protein misfolding and aggregation into amyloid species, the influences by the conditions or minor fluctuations in the initial monomeric protein structure on the speed of amyloid fibril formation, and the extent of the different types of amyloid species that can be formed, are discussed. Future perspectives in the capabilities of AFM-based 3D structural reconstruction methodology exploiting synergies with other recent AFM technology advances are also discussed to highlight the potential of AFM as an emergent general, accessible and multimodal structural biology tool for the analysis of individual biomolecules.

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An Additive-Free Model for Tau Self-Assembly

Cited by 2 publications

References 31 publications

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies

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