An adaptive planning strategy in carbon ion therapy of pancreatic cancer involving beam angle selection

Kawashima, Motohiro; Tashiro, Mitsuru; Varnava, Maria; Shiba, Shintaro; Matsui, Toshiaki; Okazaki, Shohei; Li, Yang; Komatsu, S; Kawamura, Hidemasa; Okamoto, Masahiko; Ohno, Tatsuya

doi:10.1016/j.phro.2022.01.005

Cited by 4 publications

(3 citation statements)

References 35 publications

(38 reference statements)

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“…We also found a highly robust dose distribution of BC_gantry with TM, and the dose degradation in CTV V95% was very limited (mean value: 3.8%), which was close to that of the adaptive method (mean value: 2.1%) reported in a previous study [28]. Adaptive therapy has been verified as the most effective method for improving the robustness of CIRT plans [28][29][30]. However, rapid online dose verification and quality assurance systems are still challenging.…”

Section: Discussionsupporting

confidence: 85%

Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer

Zhou

Sakai

et al. 2023

Cancers

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Carbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The study analyzed 110 computed tomography (CT) images and 600 dose distributions of eight patients with pancreatic cancer. The robustness in the beam range was evaluated using both planning and daily CT images, and two robust BCs for the rotating gantry and fixed port were selected. The planned, daily, and accumulated doses were calculated and compared after bone matching (BM) and tumor matching (TM). The dose-volume parameters for the target and organs at risk (OARs) were evaluated. Posterior oblique beams (120–240°) in the supine position and anteroposterior beams (0° and 180°) in the prone position were the most robust to WET changes. The mean CTV V95% reductions with TM were −3.8% and −5.2% with the BC for gantry and the BC for fixed ports, respectively. Despite ensuring robustness, the dose to the OARs increased slightly with WET-based BCs but remained below the dose constraint. The robustness of dose distribution can be improved by BCs that are robust to ΔWET. Robust BC with TM improves the accuracy of passive CIRT for pancreatic cancer.

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Section: Discussionsupporting

confidence: 85%

Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer

Zhou

Sakai

et al. 2023

Cancers

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“…Adaptive planning is an increasing concern in particle therapy [35] . However, the optimal method has not fully been established [36] , [37] . Through recalculation on vCTs, it may be necessary to conduct re-planning at the beginning of treatment in some cases.…”

Section: Discussionmentioning

confidence: 99%

Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer

Takaoka,

Yanagi,

Takahashi

et al. 2024

Physics and Imaging in Radiation Oncology

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“…27,148 These and many other developments promise increased process efficiency and decreased facility operational costs, coupled with improving accuracy and personalisation of PT. 22,27,31,144,145,148 They include accelerator control efficiency, higher dose rates, faster energy and beamline switching, flexible beam direction selection, and beam verification and measurement equipment and methods, as well as treatment planning algorithms and software systems, online imaging systems and image-guidance, 22,[150][151][152] motion management methods, 24,153,154 adaptive CIRT 149,155 and the application of machine learning/artificial intelligence to many aspects of PT. 156,157…”

Section: Technology Developmentsmentioning

confidence: 99%

The rationale for a carbon ion radiation therapy facility in Australia

Thwaites,

Prokopovich,

Garrett

et al. 2023

J of Medical Radiation Sci

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Australia has taken a collaborative nationally networked approach to achieve particle therapy capability. This supports the under‐construction proton therapy facility in Adelaide, other potential proton centres and an under‐evaluation proposal for a hybrid carbon ion and proton centre in western Sydney. A wide‐ranging overview is presented of the rationale for carbon ion radiation therapy, applying observations to the case for an Australian facility and to the clinical and research potential from such a national centre.

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An adaptive planning strategy in carbon ion therapy of pancreatic cancer involving beam angle selection

Cited by 4 publications

References 35 publications

Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer

Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer

Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer

The rationale for a carbon ion radiation therapy facility in Australia

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