An adaptive drug-releasing contact lens for personalized treatment of ocular infections and injuries

Sun, Rong; Zhang, Jie; Chen, Xi; Deng, Yaxin; Gou, Jingxin; Yin, Tian; He, Haibing; Tang, Xing; Ni, Xianpu; Yang, Li; Zhang, Yu

doi:10.1016/j.jconrel.2024.03.040

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Targeted and on-demand drug delivery is a cornerstone of SCL development. Sun et al ( 2024) developed an innovative contact lens that releases levofloxacin and diclofenac in response to elevated levels of reactive oxygen species (ROS) present at the site of ocular inflammation [71]. This model could be further developed not only to administer therapy, but also to monitor disease progression and treatment management.…”

Section: Dry Eyesmentioning

confidence: 99%

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Wu,

Dave,

Carbonneau

et al. 2024

Micromachines

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Smart contact lenses represent a breakthrough in the intersection of medical science and innovative technology, offering transformative potential in ophthalmology. This review article delves into the technological underpinnings of smart contact lenses, emphasizing the current landscape and advancements in biosensors, power supply, biomaterials, and the transmission of ocular information. This review further applies new innovations to their emerging role in the diagnosis, monitoring, and management of various ocular conditions. Moreover, we explore the impact of technical innovations on the application of smart contact lenses in monitoring glaucoma, managing postoperative care, and dry eye syndrome, further elucidating the non-invasive nature of these devices in continuous ocular health monitoring. The therapeutic potential of smart contact lenses such as treatment through targeted drug delivery and the monitoring of inflammatory biomarkers is also highlighted. Despite promising advancements, the implementation of smart contact lenses faces technical, regulatory, and patient compliance challenges. This review synthesizes the recent advances to provide an outlook on the state of smart contact lens technology. Furthermore, we discuss future directions, focusing on potential technological enhancements and new applications within ophthalmology.

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Section: Dry Eyesmentioning

confidence: 99%

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Wu,

Dave,

Carbonneau

et al. 2024

Micromachines

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“…Clinical manifestations may include widespread punctate defects or erosions on the corneal surface, along with continuous detachment and damage to the epithelium ( 224 ). Additionally, varying levels of inflammation affecting the ocular surface may be present ( 225 ). In severe instances, such injuries can lead to pathological alterations in the corneal stroma, potentially impacting visual acuity ( 226 ).…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Elucidating acceptance and clinical indications to support the rational design of drug-eluting contact lenses

Zhu,

Wang,

Wang

et al. 2024

International Journal of Pharmaceutics

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An adaptive drug-releasing contact lens for personalized treatment of ocular infections and injuries

Cited by 3 publications

References 48 publications

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Smart Contact Lenses in Ophthalmology: Innovations, Applications, and Future Prospects

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Elucidating acceptance and clinical indications to support the rational design of drug-eluting contact lenses

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