Abstract. Urban water distribution systems hold a critical and strategic position in preserving public health and industrial growth. Despite the ubiquity of these urban systems, aging infrastructure, and increased risk of terrorism, decision support models for a timely and adaptive contamination emergency response still remain at an undeveloped stage. Emergency response is characterized as a progressive, interactive, and adaptive process that involves parallel activities of processing streaming information and executing response actions. This study develops a dynamic decision support model that adaptively is analyzed and demonstrated using a mid-size virtual city that resembles the dynamics and complexity of real-world urban systems. This adaptive emergency response optimization model is intended to be a major component of an all-inclusive cyberinfrastructure for efficient contamination threat management, which is currently under development.