An acylamidase in mammalian liver hydrolyzing the herbicide 3,4-dichloropropionanilide

Williams, Clara H.; Jacobson, Keith H.

doi:10.1016/0041-008x(66)90009-3

Cited by 41 publications

(12 citation statements)

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“…WN'illiams and Jacobson (21) It is of interest to note that a DPA related compound, 3',4'-dichloro-2-methylvaleranilide, which is about equally herbicidal to both rice and barnyardgrass was also absorbed at the same rate by both species. The total amount absorbed, however, by the end of a 100 hour period was much less than was found for DPA.…”

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confidence: 99%

Mechanism of Selective Action of 3′,4′-Dichloropropionanilide

1968

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confidence: 99%

Mechanism of Selective Action of 3′,4′-Dichloropropionanilide

1968

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“…Matsunaka [144] outlined studies indicating that rice aryl acylamidase activity can likewise be effectively inhibited by organophosphate insecticides. In vitro inhibition by both methy1carbamate and organo-phosphate insecticides has also been observed for mammalian [146] and fungal [165] aryl acylamidase enzymes.…”

Section: Interactionsmentioning

confidence: 89%

“…5b) was shown to be catalyzed by a partially purified, particulate aryl acylamidase from rice [143,144]. Propanil hydrolyzing ability by enzyme preparations from red rice [145] and mammalian liver [146] has also been localized in particulate fractions; however, in preparations from tulip bulb [147], dandelion root [148] and fungal mycelium [149] the activity appeared to be primarily associated with the soluble component. The partially purified, soluble aryl acylamidases from tulip and dandelion were relatively insensitive to inhibition by sulfhydryl reagents which were strongly inhibitory [143] to the particulate enzyme from rice.…”

Section: Specific Metabolism In Plantsmentioning

confidence: 98%

Plant Uptake, Transport and Metabolism

Morrison

Cohen

1980

The Handbook of Environmental Chemistry

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“…Bartha & Pramer (1967) have also shown that propanil can be converted to 3,4-dichloroaniline by soil micro-organisms. Enzymes from liver homogenates of rats, mice, rabhits and dogs have been reported to catalyse the transformation of propanil to 3,4-dichloroaniline (Williams & Jacobson, 1966). Intact rice seedlings were also shown to rapidly metabolize 3',4'-dichloropropionanilide to 3,4-dichloroaniline and propionic acid (Unger, McRae & Wilson, 1964;McRae, Yih & Wilson, 1964;Still, 1968).…”

Section: Introductionmentioning

confidence: 99%

Hydrolysis of 3′,4′‐dichloropropionanilide by plant aryl acylamidases

1974

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Summary: Résumé: Zusammenfassung Thirty‐eight different agronomic and horticultural crop plants were tested for aryl acylamidase enzymes which could hydrolyse the amide bond of the herbicide, 3′,4′‐dichloropropion‐anilide (propanil). More than half of these plants, from ten different plant families, covering thirty genera, possessed enzymes capable of degrading propanil in this manner. Enzyme preparations from leaf lettuce (Lactuca sativa L.) appeared to be the richest source of aryl acylamidase activity. The total enzyme units present, as well as specific activities of enzymes from these plant tissue preparations, varied widely in the different plants. Hydrotyse du 3′,4′‐dichtoropropionanitide par des aryt acylamytases vegetates. Trente‐huit cultures différentes parmi lesquelles des plantes horticoles ont été essayées quant à la production d'aryl acylamylases, enzymes qui pourraient hydrolyser la liaison amidede l'herbicide 3′,4′‐dichloropropionanilide (propanil). Plus de la moitié de ces plantes appartenant 4 10 families différentes et représentant 30 genres possèdent des enzymes capables de dégrader le propanil de cette maniére. Des préparations enzymatiques effectuées à partir de la feuille de laitue (Lactuca sativa L.) se sont révélées être les sources les plus abondantes d'activité aryl acylamylase. Le total des unités enzymatiques présentes, aussi bien que les activités spécifiques des enzymes extraites de ces préparations de tissus végétaux ont varié de façon importante selon les especes vegétales. Hydrolyse von 3′,4′‐Dichlorpropionanilid durch pflanzliche Arytacytamidasen Es wurden 38 verschiedene landwirtschaftliche und gärtnerische Kulturpflanzen auf Arylacylamidase Enzyme untersucht, die die Amidbindung des Herbizids 3′,4′‐Dichlor‐propionanilid (Propanil) hydrolysieren konnten. Mehr als die Hälfte dieser Pflanzen, aus zehn verschiedenen Pflanzenfamilien, 30 Gattungen einschliessend, enthielten Enzyme, die Propanil auf diese Weise abzubauen vermochten. Enzymprapärationen von Kopfsalat (Lactuca sativa L.) schienen die ergiebigste Quelle für die Arylacylamidase‐Aktivität zu sein. Die insgesamt vorhandenen Enzymeinheiten, als auch die spezifischen Aktivitäten der Enzyme der Gewebepräparationen, schwankten bei den verschiedenen Pflanzen ziemlich stark.

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An acylamidase in mammalian liver hydrolyzing the herbicide 3,4-dichloropropionanilide

Cited by 41 publications

References 4 publications

Mechanism of Selective Action of 3′,4′-Dichloropropionanilide

Mechanism of Selective Action of 3′,4′-Dichloropropionanilide

Plant Uptake, Transport and Metabolism

Hydrolysis of 3′,4′‐dichloropropionanilide by plant aryl acylamidases

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