An acute rat in vivo screening model to predict compounds that alter blood glucose and/or insulin regulation

Brott, David; Diamond, M. P.; Campbell, P. S.; Zuvich, Andy; Cheatham, Letitia; Bentley, Patricia; Gorko, Mary Ann; Fikes, James; Saye, Joanne

doi:10.1016/j.vascn.2013.06.003

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…The data included in the analysis was gathered from previously published studies, in which IVGTTs were performed; the studies are summarized in Table and included data from dogs ( n = 11), humans ( n = 24), mice ( n = 10), pigs ( n = 11), and rats ( n = 16). In the study performed in dogs and one of the human studies, a bolus dose of insulin was administered 20 minutes after the glucose dose; so‐called insulin‐modified IVGTT.…”

Section: Methodsmentioning

confidence: 99%

“…To determine if the allometrically scaled model can describe data from other studies as well as for a species that the model has not been developed on, the mean and SDs of glucose and insulin concentrations from published IVGTT studies performed in dogs, humans, pigs, monkeys, and rats were digitalized . Mice were not included because no study that fulfilled the inclusion criteria and presented glucose and insulin profiles was found for this species, except the study used for data analysis .…”

Section: Methodsmentioning

confidence: 99%

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Model‐Based Interspecies Scaling of Glucose Homeostasis

Alskär

Karlsson

Kjellsson

2017

CPT Pharmacom & Syst Pharma

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Being able to scale preclinical pharmacodynamic response to clinical would be beneficial in drug development. In this work, the integrated glucose insulin (IGI) model, developed on clinical intravenous glucose tolerance test (IVGTT) data, describing dynamic glucose and insulin concentrations during glucose tolerance tests, was scaled to describe data from similar tests performed in healthy rats, mice, dogs, pigs, and humans. Several approaches to scaling the dynamic glucose and insulin were investigated. The theoretical allometric exponents of 0.75 and 1, for clearances and volumes, respectively, could describe the data well with some species‐specific adaptations: dogs and pigs showed slower first phase insulin secretion than expected from the scaling, pigs also showed more rapid insulin dependent glucose elimination, and rodents showed differences in glucose effectiveness. The resulting scaled IGI model was shown to accurately predict external preclinical IVGTT data and may be useful in facilitating translations of preclinical research into the clinic.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Model‐Based Interspecies Scaling of Glucose Homeostasis

Alskär

Karlsson

Kjellsson

2017

CPT Pharmacom & Syst Pharma

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Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats

Zhang

Chen

Guo

et al. 2017

Chinese Journal of Natural Medicines

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Research-Relevant Clinical Pathology Resources: Emphasis on Mice, Rats, Rabbits, Dogs, Minipigs, and Non-Human Primates

Bau‐Gaudreault

Arndt

Provencher³

et al. 2021

ILAR Journal

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Clinical pathology testing for investigative or biomedical research and for preclinical toxicity and safety assessment in laboratory animals is a distinct specialty requiring an understanding of species specific and other influential variables on results and interpretation. This review of clinical pathology principles and testing recommendations in laboratory animal species aims to provide a useful resource for researchers, veterinary specialists, toxicologists, and clinical or anatomic pathologists.

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An acute rat in vivo screening model to predict compounds that alter blood glucose and/or insulin regulation

Cited by 3 publications

References 33 publications

Model‐Based Interspecies Scaling of Glucose Homeostasis

Model‐Based Interspecies Scaling of Glucose Homeostasis

Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats

Research-Relevant Clinical Pathology Resources: Emphasis on Mice, Rats, Rabbits, Dogs, Minipigs, and Non-Human Primates

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