An Acute Brucellosis Case Presented with Pancytopenia and Hepatitis

Bilek, Heval Can; Alanbayı, Ümit; Bal, Tayibe

doi:10.5798/dicletip.363935

Cited by 2 publications

(2 citation statements)

References 6 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Generally, the chief complaint is fever, either alone or with local symptoms, and the progression is more favorable in children than adults with a better response to medication 18 . Acute disease is typically associated with symptoms and findings such as fever, night sweats, arthralgia, myalgia, lumbar pain, headache, dizziness, depression and anorexia 19,20 . However, physical examination findings are quite variable and hepatomegaly, splenomegaly, and lymphadenomegaly may also be encountered6.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Brucellosis and Hepatitis B Virus Seropositivity in Patients with Chronic Lymphocytic Leukemia

et al. 2020

View full text Add to dashboard Cite

Objective: Patients with chronic lymphocytic leukemia (CLL) show defective cellular and humoral immune responses. Although such immune failure is known to be associated with an increase in the frequency of particularly gram-positive and-negative bacterial infections, data on the increase in the frequency of zoonoses such as brucellosis and viral infections such as the hepatitis B virus (HBV) are inconclusive. This study aims to investigate the frequency of brucellosis and HBV seropositivity in patients diagnosed with CLL. Methods: Patients followed-up for CLL between 2005 and 2019 were evaluated. Results of patients who were tested for HBsAg and anti-HBs serology using the ELISA assay and for brucellosis using the serum agglutination (Wright) test were recorded. Demographic data and laboratory results of all patients included in the study were evaluated. Results: This study included 188 patients diagnosed with CLL, of whom 56 (29.8%) were female and 132 (70.2%) were male. Median age was 62 (33-92) years. Complete blood count parameters at diagnosis were as follows: median leukocyte count, 54.4×109/L (5.1-312.3×109/L); median lymphocyte count, 42.3×109/L (2.8-296.8×109/L); median platelet count, 148×109/L (86.3-342.3×109/L); median hemoglobin level, 13.4 g/dL (8.5-16.9 g/dL). HBsAg and anti-HBs were tested in 142 patients. A total of 16 (11.27%) patients were HBsAg-positive; with 5 (3.52%) positive cases in females and 11 (7.75%) in males. A total of 105 (73.95%) patients were anti-HBs-positive; with 32 (22.54%) positive cases in females and 73 (51.41%) in males. Wright agglutination test was performed on 82 patients. A total of 4 (4.88%) patients reacted positively to the Wright test; with 3 (3.66%) positive cases in females and 1 (1.22%) in males. Conclusion: Compared with the epidemiological studies conducted in the same region; the rate of positive reactions to the Wright agglutination test was consistent with the literature data; however, a higher rate of HBsAg positivity was determined. This may be linked to the increase in the risk of HBV transmission due to the immune defect caused by CLL or the immunosuppressive picture induced by the medication used in the treatment, or viral reactivation.

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of Brucellosis and Hepatitis B Virus Seropositivity in Patients with Chronic Lymphocytic Leukemia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Lökopeni %8-38 arasında değişen oranlarda bildirilirken, olguların %2-16'inda trombositopeni bildirilmiştir 3 . Bruselloz ayrıca nadiren pansitopeniye neden olabilmektedir 6 .…”

Section: Introductionunclassified

Çocukluk çağı Brusellozunda Hematolojik Bulgular: Türkiye’nin Güneydoğusundan bir analiz

Sal

Akın

2022

Dicle Tıp Dergisi

View full text Add to dashboard Cite

Amaç: Bruselloz Türkiye’de endemik bir zoonozdur. Çocuklarda brusellozun hematolojik bulguları hakkında sınırlı veri mevcuttur. Bu çalışmada çocukluk çağı brusellozunun hematolojik bulgularının değerlendirilmesi amaçlandı. Yöntemler: Türkiye’nin Güneydoğusundaki bir hastanenin çocuk hematoloji polikliniğine sitopeni nedeniyle sevk edilen ve bruselloz tanısı alan hastaların tıbbi kayıtları geriye dönük olarak incelendi. Bulgular: Çalışmaya yaş ortalaması 9.2±3.7 yıl (yaş aralığı: 3-14) olan 17 hasta alındı. Hastalar çoğunlukla erkek (n=11, %64,7) idi. Ateş ve eklemlerde ağrı en sık başvuru yakınmalarıydı (sırasıyla n=9, %52,9 ve n=6, %35,3). En sık görülen hematolojik bulgu 11 hastada (%64,7) anemi iken, bunu sırasıyla 10 hastada (%58,8) trombositopeni ve beş hastada (%29,4) lökopeni izliyordu. Pansitopeni üç hastada (3/17, %17,6) saptandı. Ortanca hemoglobin düzeyi, trombosit sayısı ve lökosit sayısı sırasıyla, 10.8 g/dL (IQR 9.5-12.8), 148×109/L (IQR 117-167) ve 5.4 ×109/L (IQR 3.9-7.2) idi. Altı hastada C-reaktif protein (CRP) (6/9, %66,6) ve beş hastada ferritin (5/14, %35,7) yüksekliği saptandı. Sadece iki hastada alanin aminotransferaz (ALT) yüksekliği bulundu (2/16, %12,5). Hastaların ortanca serum Brusella aglütinasyon titresi 1:1280 (IQR 320-1280) idi. Hiçbir hastada hastaneye yatışı gerektirecek bir komplikasyon gelişmedi ve hepsine altı hafta süreli kombine antibiyotik tedavisi verildi. Tedavinin dördüncü haftasında hematolojik anormalliklerin düzeldiği görüldü. Sonuç: Bruselloza bağlı hematolojik bulgular genellikle ciddi değildir ve sadece bruselloz için verilen antibiyotik tedavisi ile tam iyileşme sağlanabilmektedir.

show abstract

An Acute Brucellosis Case Presented with Pancytopenia and Hepatitis

Cited by 2 publications

References 6 publications

Frequency of Brucellosis and Hepatitis B Virus Seropositivity in Patients with Chronic Lymphocytic Leukemia

Frequency of Brucellosis and Hepatitis B Virus Seropositivity in Patients with Chronic Lymphocytic Leukemia

Çocukluk çağı Brusellozunda Hematolojik Bulgular: Türkiye’nin Güneydoğusundan bir analiz

Contact Info

Product

Resources

About