We present the new THOT toolkit for fullyautomatic and interactive statistical machine translation (SMT). Initial public versions of THOT date back to 2005 and did only include estimation of phrase-based models. By contrast, the new version offers several new features that had not been previously incorporated. The key innovations provided by the toolkit are computeraided translation, including post-editing and interactive SMT, incremental learning and robust generation of alignments at phrase level. In addition to this, the toolkit also provides standard SMT features such as fully-automatic translation, scalable and parallel algorithms for model training, client-server implementation of the translation functionality, etc. The toolkit can be compiled in Unix-like and Windows platforms and it is released under the GNU Lesser General Public License (LGPL).