An activatable near-infrared fluorescent probe targeting CKIP-1 for monitoring osteoporosis in vivo

Yang, Xi; Ding, Yi; Wang, Xiaolu; Dai, Hongmiao; Xu, Haifeng; Wu, Bo; He, Xiaoyang; Zhang, Yuxuan; Li, Xin; Jin, Yiguang; Chu, Chun-Ping; Peng, Jiang; Cui, Yu; Zhang, Lingqiang

doi:10.1016/j.snb.2021.130453

Cited by 1 publication

(2 citation statements)

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“…Therefore, detecting CEs activity was extremely important for studying the relationship between CEs and drug metabolism, which will guide us to use drugs reasonably for related diseases therapy. 5-fluorouracil (5-FU), an antitumor drug, has been proven to up-regulate CEs activity in HepG2 cells [12,16]. In view of this, the feasibility of using probe TTAP−AB to monitor the activity of CEs regulated by the drug 5-FU has been investigated.…”

Section: Cell Imaging Of Cesmentioning

confidence: 99%

“…Among them, fluorescent probe attracted the great attentions owing to its advantages of simple operation, fast detection, high spatiotemporal resolution, and noninvasive imaging in living systems [9]. At present, a plenty of fluorescent probes have been reported based on various mechanisms, including photoinduced electron transfer (PET) [10][11][12], intramolecular charge transfer (ICT) [13][14][15][16][17][18], and other mechanisms [19][20][21][22]. However, these probes still suffered from various drawbacks in practical 2 applications.…”

Section: Introductionmentioning

confidence: 99%

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An Innovative Aggregation-Induced Emission-Based NIR Fluorescent Probe for Visualizing Carboxylesterases in Living Cells, Zebrafish and Tumor-Bearing Mice

Gao,

Chen,

Liu

et al. 2024

Preprint

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In human body, carboxylesterases (CEs) play the crucial roles in xenobiotic metabolism and lipid homeostasis. But the abnormal CEs expression is highly associated with some diseases, such as hyperlipidemia, diabetes and liver cancer. Therefore, it is of great significance to develop an efficient tool for the accurate detection of CEs in living organisms. Herein, an innovative near-infrared (NIR) fluorescent probe TTAP−AB has been designed for CEs detection based on aggregation-induced emission (AIE) mechanism. This probe exhibits rapid response (2 min), excellent sensitivity (limit of detection = 8.14×10−6 U/mL), and high selectivity towards CEs. Additionally, owing to the good biocompatibility, probe TTAP−AB enables to monitor the dynamic changes of CEs level under drug-induced modulation in living cells and zebrafish. More importantly, probe TTAP−AB is successfully employed to image the liver tumor and assist tumor resection by the real-time monitoring of CEs, indicating that TTAP−AB is promising to guide liver cancer surgery. Therefore, probe TTAP−AB can not only enrich the strategies for CEs detection in biological systems, but also has great potential for some clinical imaging applications, including medical diagnosis, preclinical research, and imaging-guided surgery.

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Section: Cell Imaging Of Cesmentioning

confidence: 99%