An ACTH-secreting Pituitary Adenoma Within the Sphenoid Sinus

Suzuki, Kunihiro; Hattori, Yoshiyuki; Aoki, Chie; Nakano, Ayuko; Tomizawa, Atsuko; Kase, Hiroyuki; Kasai, Kikuo

doi:10.2169/internalmedicine.49.2477

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Cited by 2 publications

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“…The best treatment option for Cushing's disease is when the responsible corticotroph adenoma can be entirely removed surgically by the trans-sphenoidal approach, with sufficient skill to preserve normal anterior pituitary function (32,46). This induces remission in approximately 80% of the patients, but long-term relapse occurs in up to 30% of these cases (45).…”

Section: Managementmentioning

confidence: 99%

Functioning Pituitary Adenoma

Sharif-Alhoseini¹,

Laws²,

Rahimi‐Movaghar³

2012

Pituitary Adenomas

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Section: Managementmentioning

confidence: 99%

Functioning Pituitary Adenoma

Sharif-Alhoseini¹,

Laws²,

Rahimi‐Movaghar³

2012

Pituitary Adenomas

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Ectopic ACTH-secreting pituitary adenomas within the sphenoid sinus

et al. 2014

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Ectopic pituitary adenomas are defined by the presence of adenomatous pituitary tissue outside the sella and distinctly separate from the pituitary gland. Ectopic ACTH-secreting pituitary adenomas (EAPAs) are a rare cause of Cushing's syndrome. Detecting these radiologically can prove difficult, in part, due to their typically small size and unpredictable anatomical location. In ACTH-dependent Cushing's syndrome, if, despite comprehensive testing, the source of excess ACTH remains occult (including negative work up for ectopic ACTH syndrome) thought should be given to the possibility of the patient harboring an EAPA. In most cases, ectopic ACTH pituitary adenomas within the sphenoid sinus will manifest with symptoms of hormonal excess, have an obvious sphenoid sinus mass on pre-operative imaging and will demonstrate resolution of hypercortisolism after surgical excision if located and removed. Twenty cases of EAPAs have been reported in the literature to date. This paper will review the current literature on all previously reported EAPAs within the sphenoid sinus in addition to the current case.

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An ACTH-secreting Pituitary Adenoma Within the Sphenoid Sinus

Abstract: Abstract

Cited by 2 publications

References 19 publications

Functioning Pituitary Adenoma

Functioning Pituitary Adenoma

Ectopic ACTH-secreting pituitary adenomas within the sphenoid sinus

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