An acneiform eruption exhibiting locus minoris resistentiae after whole‐brain radiation and vemurafenib therapy

Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin

“…En cambio, se han descrito hasta en un 77% de los pacientes tratados en monoterapia con el inhibidor MEK trametinib [5]. En la literatura hay descritos 5 casos de reacciones acneiformes tras tratamiento con vemurafenib [6,7,8]. Todas ellas se iniciaron en menos de 5 semanas de inicio del tratamiento y la mayoría de ellas respondió a tratamiento tópico u observación [6].…”

Graft versus host disease localized to striae distensae: An example of locus minoris resistentiae

“…An easy transit and access of lymphocytes to cutaneous antigens through the damaged dermal matrix in the striae might be a plausible explanation for this occurrence. Chemotherapy-induced skin eruptions localized to radiotherapy site 4 and melanoma metastasis; 5 as well as infective conditions like verruca 6 and tinea barbae 7 localized to verrucous epidermal nevus and scar tissue, respectively, are other examples of locus minoris resistentiae. Fixed drug reaction secondary to minocycline localizing to areas of herpes zoster and burn scars has also been described.…”