An accurate, fast and robust method to generate patient-specific cubic Hermite meshes

Lamata, Pablo; Niederer, Steven A.; Nordsletten, David; Barber, D C; Roy, Ian; Hose, Rod; Smith, Nic

doi:10.1016/j.media.2011.06.010

Cited by 93 publications

(105 citation statements)

References 31 publications

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“…Each data set was segmented using the Philips heart atlas based segmentation tool [13]. We use the meshing tool developed by Lamata et al [32,33] to fit a cubic order finite element mesh to each segmented data set. Figure 7C shows the resulting finite element meshes.…”

Section: Multi-scale Modelmentioning

confidence: 99%

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

Land

Park-Holohan

Smith

et al. 2017

Journal of Molecular and Cellular Cardiology

103

147

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Experimental data from human cardiac myocytes at body temperature is crucial for a quantitative understanding of clinically relevant cardiac function and development of whole-organ computational models. However, such experimental data is currently very limited. Specifically, important measurements to characterize changes in tension development in human cardiomyocytes that occur with perturbations in cell length are not available. To address this deficiency, in this study we present an experimental data set collected from skinned human cardiac myocytes, including the passive and viscoelastic properties of isolated myocytes, the steady-state force calcium relationship at different sarcomere lengths, and changes in tension following a rapid increase or decrease in length, and after constant velocity shortening. This data set is, to our knowledge, the first characterization of length and velocity-dependence of tension generation in human skinned cardiac myocytes at body temperature.We use this data to develop a computational model of contraction and passive viscoelasticity in human myocytes. Our model includes troponin C kinetics, tropomyosin kinetics, a three-state crossbridge model that accounts for the distortion of crossbridges, and the cellular viscoelastic response. Each component is parametrized using our experimental data collected in human cardiomyocytes at body temperature. Furthermore we are able to confirm that properties of length-dependent activation at 37• C are similar to other species, with a shift in calcium sensitivity and increase in maximum tension. We revise our model of tension generation in the skinned isolated myocyte to replicate reported tension traces generated in intact muscle during isometric tension, to provide a model of human tension generation for multi-scale simulations. This process requires changes to calcium sensitivity, cooperativity, and crossbridge transition rates. We apply this model within multi-scale simulations of biventricular cardiac function and further refine the parametrization within the whole organ context, based on obtaining a healthy ejection fraction. This process reveals that crossbridge cycling rates differ between skinned myocytes and intact myocytes.

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Section: Multi-scale Modelmentioning

confidence: 99%

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

Land

Park-Holohan

Smith

et al. 2017

Journal of Molecular and Cellular Cardiology

103

147

View full text Add to dashboard Cite

show abstract

“…The template image space provides a common reference space for population-based shape analysis (Hoogendoorn et al, 2013). The template surface mesh can be used to generate a personalised patient-specific mesh for biomechanical simulation (Lamata et al, 2011). The statistical shape model can be used as prior knowledge to guide image segmentation (Heimann and Meinzer, 2009).…”

Section: Related Workmentioning

confidence: 99%

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Bai

Shi

Marvao

et al. 2015

Medical Image Analysis

122

116

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“…http://www.cmiss.org/cmgui/wiki/\ /TheCmguiEXFormatGuideExnodeAndExelemFiles shape coefficients for each patient. In the construction of an atlas, shapes are encoded in computational meshes through an automatic personalization process from the segmented images [11], [12]. Then, a reduction of the number of shape dimensions is performed through a principal component analysis (PCA).…”

Section: Aca Descriptionmentioning

confidence: 99%

“…Once the image set is made available, a computational mesh is automatically fitted to each segmented anatomy [11], [12]. This process runs through a web interface to the heartgen web service [14] relaying on LOBCDER as distributed file manager to provide a shared storage space to fetch data, images, and return analysis results.…”

Section: Running Aca With Lobcdermentioning

confidence: 99%

Distributed Data Management Service for VPH Applications

Koulouzis

Belloum

Bubak

et al. 2016

IEEE Internet Comput.

Self Cite

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Abstract-For many medical applications it is challenging to transparently access large datasets, often hosted across different domains on heterogeneous infrastructures. Homogenizing the infrastructure to simplify data access is unrealistic, therefore, it is important to elaborate a distributed storage which doesn't introduce added complexity. The main objective of this research is to investigate a solution that flexibly federates data on clouds or grids without any changes to the existing infrastructure and to be able to scale with the increasing data demand. Unlike existing approaches, ours isnt bound to a specific technology and doesn't require from administrators, users or application developers additional effort to federate and use the storage infrastructure. The elaborated system is implemented on the VPH-Share infostructure. As an example, we present a cardiac anatomy analysis workflow which uses the proposed solution to support a novel diagnostic method to characterize the shape of the heart.

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An accurate, fast and robust method to generate patient-specific cubic Hermite meshes

Cited by 93 publications

References 31 publications

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion

Distributed Data Management Service for VPH Applications

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