An absorbable thread suture technique to treat snoring

Kwon, Ji-Won; Kong, Tae Hoon; Ha, Tae Hyoung; Park, Dong Joon

doi:10.1007/s00405-015-3722-6

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Early bioresorbable implants have only performed simple functions to support some parts of the human body such as blood vessels, key organs, and bones. [67][68][69][70][71][72] These implants showed functionality similar to that of conventional medical implants, although with the base materials converted to bioresorbable ones that could disappear after a certain time. In addition to structural support, bioresorbable implants can also be applied in drug delivery systems.…”

Section: Bioresorbable E-drugs For Monitoring and Treating Short-term Diseasesmentioning

confidence: 99%

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

et al. 2021

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pharmaceutical drug delivery and healthcare systems. E-drugs are biocompatible electronic devices capable of identifying specific biological analytes (e.g., glucose, enzymes, and other biomolecules), [1,2] environmental stimuli (e.g., strain, pressure, and external temperature), and electrophysiological signals (e.g., electrocardiograms (ECG), electromyograms (EMG), and electroencephalography (EEG)) to monitor health status and deliver therapeutic treatments in a controlled manner via wireless prompts. [3][4][5] Owing to their innovative functions and technologies, e-drugs have been widely adopted in pharmaceutical and medical research to monitor and treat chronic diseases, which are still considered difficult to cure. Conventional pharmaceutical treatments or medical procedures for chronic diseases encounter a major obstacle in patient compliance, as they involve regular drug intake or treatments. [6] For example, patients with diabetes are recommended to collect blood samples to measure their glucose levels twice a day. However, the International Diabetes Management Practice Study reported that only 29.7-38.5% of patients with type-2 diabetes in Asia, Eastern Europe, and Latin America self-monitor their glucose levels, which hinders effective management of their condition. [7] As a strategy to improve patients' adherence to drug intake and treatments, electronic devices capable of continuously monitoring biological signal levels and therapeutic response via wireless applications have been demanded by the markets.The fundamental differences between electronics and biological tissues have emerged as a challenge in the development of an advanced generation of e-drugs. For instance, soft biological tissues have a low modulus of elasticity, which is typically less than 100 kPa, and high moisture content. By contrast, conventional electronics are generally made of electronic materials such as metals and silicone, which are stiff, with modulus greater than 80 GPa, dry, and static. [8] This mechanical and physical mismatch between human tissues and electronics causes adverse clinical outcomes. Major consequences include inflammatory responses induced by the micromotion of the implant, during and after implantation, as well as scar tissue and fibrotic encapsulation, which substantially compromises the performance and lifetime of e-drugs. [9,10] Recent advances in diagnostics and medicines emphasize the spatial and temporal aspects of monitoring and treating diseases. However, conventional therapeutics, including oral administration and injection, have difficulties meeting these aspects due to physiological and technological limitations, such as long-term implantation and a narrow therapeutic window. As an innovative approach to overcome these limitations, electronic devices known as electronic drugs (e-drugs) have been developed to monitor real-time body signals and deliver specific treatments to targeted tissues or organs. For example, ingestible and patch-type e-drugs could detect changes in biomarkers at the target s...

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Section: Bioresorbable E-drugs For Monitoring and Treating Short-term Diseasesmentioning

confidence: 99%

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

et al. 2021

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“…[4][5][6] However, the molecule of PLA is a type of large ester molecule possessing many ester bonds, which leads to high hydrophobicity for PLA sutures, so that the PLA sutures possess poor biocompatibility and cellular affinity. [7][8][9] Therefore, in order to improve the biocompatibility and cellular affinity of PLA sutures, it is necessary to increase its hydrophilicity. Some experts have adopted two methods to improve the hydrophilicity of PLA sutures as follows.…”

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confidence: 99%

Enhanced surface hydrophilicity of polylactic acid sutures treated by lipase and chitosan

Liu

et al. 2018

Textile Research Journal

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Polylactic acid (PLA) surgical sutures are a new type of absorbable sutures that can be degraded and absorbed in the body. However, there is high hydrophobicity for the surface of PLA sutures, which leads to poor biocompatibility and cellular affinity. In order to increase the hydrophilicity, the PLA sutures were etched by lipase firstly, and then grafted with chitosan. The results indicate that the optimal conditions of treating PLA sutures by lipase were as follows: 45℃ reaction temperature, 4.5 g/L concentration of lipase and 8 h reaction time. The sutures were etched by lipase and then formed some grooves and a number of hydroxyl (-OH) bonds, which led to increased surface area and hydrophilicity, but a drop in mass and strength. The optimal conditions of grafting chitosan onto PLA sutures were as follows: 4 h reaction time and 3 g/L concentration of chitosan. The chitosan grafted and loaded on the surface of PLA sutures, and in some areas of the sutures the chitosan reunited, which led to a rough surface and large friction coefficient. Finally, the hydrophilicity of the PLA sutures, treated by lipase and then grafted with chitosan, was greatly improved.

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Is the remedy temporary surgical procedures in primer snoring?

Acar

Dağlı

2016

Eur Arch Otorhinolaryngol

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An absorbable thread suture technique to treat snoring

Cited by 3 publications

References 29 publications

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

Enhanced surface hydrophilicity of polylactic acid sutures treated by lipase and chitosan

Is the remedy temporary surgical procedures in primer snoring?

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