An absent inferior vena cava in a pediatric renal transplant recipient

Arrazola, Luis; Long, Alexander; Moss, Adyr; Sozen, Hakan; Najarían, John S.

doi:10.1034/j.1399-0012.2000.140414.x

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Pediatric kidneys have cautiously been utilized in many transplant centers as an additional source of organs for adult recipients. The use of pediatric kidney donors is controversial based on several reports demonstrating poor functional outcome, a higher incidence of rejection, worse graft and patient survival rates and a higher incidence of surgical complications including vascular thrombosis, renal artery stenosis, hydronephrosis and urinary leak (6)(7)(8)(9). In addition, concerns have been raised over the difference between donor renal mass and recipient body mass index (BMI) (10).…”

Section: Introductionmentioning

confidence: 99%

Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Fernández

Turgeon

Odorico

et al. 2004

American Journal of Transplantation

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The shortage of cadaveric donors for simultaneous pancreas-kidney transplantation has prompted the use of cadaveric organs from pediatric donors. The long-term outcome and its impact on overall longterm survival are unknown. A total of 680 recipients receiving cadaver Simultaneous pancreas-kidney (SPK) transplantation from pediatric and adult donors between July 1986 and September 2001 were analyzed and compared. Ten-year kidney and pancreas graft survival for SPK transplantation from donors aged <18 years (n = 142) were 80% and 72%, respectively, compared to 61% pancreas and kidney graft survival from donors ≥18 years of age (n = 538; p = 0.03 and 0.05, respectively). Five years post-transplant, blood glucose, HbA 1 c and creatinine clearance were significantly better in recipients from pediatric donors (85.3 ± 13 mg/dL, 5.5 ± 3.5% and 65.6 ± 16 mL/min, respectively), compared to recipients from adult donors (95.1 ± 29 mg/dL, 5.9 ± 3.5% and 58.3 ± 17 mL/min; p = 0.001, 0.01 and 0.002, respectively). Causes of graft failure for kidney and pancreas transplants were similar between the two groups. No statistically significant difference was observed in patient survival between recipients from pediatric donors compared to adult donors (85% vs. 76%, p = 0.29). When recipients of SPK from pediatric donors were stratified according to age (3-11 years and 12-17 years) and compared, no difference in kidney or pancreas graft survival was observed (kidney 76.4% vs. 81.3%, p = 0.15; pancreas 75% vs. 76%, p = 0.10, respectively). Pediatric donors represent a valuable source of organs, providing excellent short-and long-term outcomes. Wide utilization of pediatric organs will substantially increase the donor pool.

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Section: Introductionmentioning

confidence: 99%

Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Fernández

Turgeon

Odorico

et al. 2004

American Journal of Transplantation

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“…In the absence of early symptoms, absence of the IVC can manifest as hypertension, cyanosis, dyspnea, heart failure, cardiac enlargement, and childhood developmental delay. 9 In other cases, it may be manifested symptomatically by chronic venous occlusion with associated skin changes, such as severe edema or leg ulcers, 2 or it can be a potential independent risk factor for venous thromboembolism.…”

Section: Discussionmentioning

confidence: 99%

Lower limb ulcers due to an absent inferior vena cava

2022

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“…Embryogenesis of the inferior cava is complete by the eighth week and is a complex process involving the formation and regression of different venous systems (5,6,(11)(12)(13). The three main venous drainage systems in the embryo (see Figs.…”

Section: Discussionmentioning

confidence: 99%

“…In the general population, isolated IVC agenesis is rare (0.3%) . However, this anatomical finding becomes more common in the context of polysplenia syndromes or congenital cardiomyopathies . The exact etiology is unknown, but it is thought to arise either during embryonic development or as a consequence of perinatal thrombosis .…”

Section: Discussionmentioning

confidence: 99%

“…An absent IVC is invariably an asymptomatic condition. In adulthood, IVC agenesis has been found to be associated with deep venous thrombosis . The increased risk of deep venous thrombosis is thought to be due to venous ectasia and inadequacy of the collateral venous return, combined with up to a third of patients with IVC abnormalities being found to be hypercoagulable .…”

Section: Discussionmentioning

confidence: 99%

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