An Abraded Surface of Doxorubicin-Loaded Surfactant-Containing Drug Delivery Systems Effectively Reduces the Survival of Carcinoma Cells

Abstract

An effective antitumor remedy is yet to be developed. All previous approaches for a targeted delivery of anticancer medicine have relied on trial and error. The goal of this study was to use structural insights gained from the study of delivery systems and malignant cells to provide for a systematic approach to the development of next-generation drugs. We used doxorubicin (Dox) liposomal formulations. We assayed for cytotoxicity via the electrical current exclusion method. Dialysis of the samples yielded information about their drug release profiles. Information about the surface of the delivery systems was obtained through synchrotron small-angle X-ray scattering (SAXS) measurements. SAXS measurements revealed that Dox-loading yielded an abraded surface of our Dox liposomal formulation containing soybean oil, which also correlated with an effective reduction of the survival of carcinoma cells. Furthermore, a dialysis assay revealed that a higher burst of Dox was released from soybean oil-containing preparations within the first five hours. We conclude from our results that an abraded surface of Dox-loaded drug delivery system increases their efficacy. The apparent match between surface geometry of drug delivery systems and target cells is suggested as a steppingstone for refined development of drug delivery systems. This is the first study to provide a systematic approach to developing next-generation drug carrier systems using structural insights to guide the development of next-generation drug delivery systems with increased efficacy and reduced side effects.

Fresh Carrier for an Old Topical Local Anesthetic: Benzocaine in Nanostructured Lipid Carriers

“…Interestingly, the Guinier–Porod exponent, providing information on the nanoparticle surface, remained the same: −4.0 (NLC) and −4.2 (NLC BZC ) at 25, 37, and 40 °C. According to it, both NLC and NLC BZC exhibited smooth surfaces, which can indicate drug dispersion into the lipid matrix, without the adsorption of unencapsulated molecules in the nanocarrier surface . BZC did not change the radius of gyration nor change the surface of the nanoparticle, as observed in other NLC systems, confirming the dispersion of the anesthetic inside the nanoparticles.…”

Epigenetics—Shedding Light on the Path Ahead for Material Sciences

“…To illustrate the point from another perspective, material sciences, in this case developing formulations for anti-cancer-medication, relies upon the principle of trial and error. However, one publication suggests an alternative path [17]. The authors are not going so far as to suggest they found the holy grail, but getting a sense of how to streamline the pipeline would probably be seen as advantageous by many.…”