An Abnormal Chromosome in Chronic Lymphocytic Leukaemia

Gunz, F. W.; Fitzgerald, P. H.; Adams, Angela

doi:10.1136/bmj.2.5312.1097

Cited by 128 publications

(12 citation statements)

References 5 publications

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“…The Christchurch chromosome, a deletion of the short arm of a group G chro mosome, was originally suggested to predispose to chronic lymphocytic leukemia (129). The original association now seems to have been fortui tous, since a number of examples of the Christchurch chromosome have been observed in normal persons (1,95).…”

Section: Chromosome Studiesmentioning

confidence: 98%

Human Genetics

Sutton

1967

Annu. Rev. Genet.

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Studies of human heredity have advanced in many areas and have con tributed to the understanding of basic genetic mechanisms. To enumerate all the advances is beyond the scope of the assignment (and the abilities of the reviewer), not to mention the page limitations imposed by the editors. Those papers discussed here are a sample, hopefully not random, of de velopments primarily in 1965 and 1966. This period was selected in part be cause of the excellent review of human genetics assembled for the Cold Spring Harbor Symposium in 1964 (64).

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Section: Chromosome Studiesmentioning

confidence: 98%

Human Genetics

Sutton

1967

Annu. Rev. Genet.

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“…Evidence of a short arm deletion in the G group chromosomes has recently been presented by several authors (Gunz et al 1962, Shaw 1962, Migeon 1965, Subrt and Brychnac 1966, Neu et al 1966. It is a general feature that this aberration is not associated with any particular disease.…”

mentioning

confidence: 92%

A Preliminary Note on a Case of Trisomic Down's Syndrome with a Short Arm Deletion of a G Group (21-22) Chromosome

Ito

Makino

1966

Proceedings of the Japan Academy

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“…The development of treatment approaches for B-CLL has lagged in comparison to other hematologic malignancies for various reasons. B-CLL disease seems especially prone to familial occurrence being nearly 3 times higher than that expected for the general population [3]. Historical reports exists for identical twins [4], mother and son [5], grandfather, son, and grandson [6] affected due to familial aggregation of chronic lymphocytic leukaemia pathogenesis associated with immune defects.…”

Section: Introductionmentioning

confidence: 99%

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients

Tummala¹,

Goltsov²,

Khalil³

et al. 2012

Biodiscovery

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Conflict of Interests:No potential conflict of interest was disclosed and there is not any competing financial interest in relation to the work described. AbstractThe clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival? In recent years, mathematical modelling has contributed significantly in understanding the complexity of diseases. In order to build a mathematical model for determining prognosis of B-CLL one has to identify, characterise and quantify key molecules involved in the disease. Here we discuss the need and role of mathematical modelling in predicting B-CLL disease pathogenesis and suggest a new systems biology approach for a personalised therapy of B-CLL patients.

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An Abnormal Chromosome in Chronic Lymphocytic Leukaemia

Cited by 128 publications

References 5 publications

Human Genetics

Human Genetics

A Preliminary Note on a Case of Trisomic Down's Syndrome with a Short Arm Deletion of a G Group (21-22) Chromosome

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients

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