An abnormal cerebroplacental ratio (CPR) is predictive of early childhood delayed neurodevelopment in the setting of fetal growth restriction

Monteith, Cathy; Flood, Karen; Pinnamaneni, Ragamallika; Levine, Terri A.; Alderdice, Fiona; Unterscheider, Julia; McAuliffe, Fionnuala M.; Dicker, Patrick; Tully, Elizabeth; Malone, Fergal D.; Foran, Adrienne

doi:10.1016/j.ajog.2019.06.026

Cited by 42 publications

(41 citation statements)

References 32 publications

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“…Therefore, fetal growth should be followed up in COVID-19 infected pregnant patients. Additional ultrasound evaluation at gestational age 24-28-32-36 weeks with biometry, amniotic fluid measurement and assessment of uterine artery Doppler pulsatility index and midcerebral artery Doppler in case of IUGR <10th percentile) is indicated [45,46].…”

Section: Pregnancy Complications: What Are the Risks For The Pregnancy?mentioning

confidence: 99%

ISIDOG Recommendations Concerning COVID-19 and Pregnancy

Donders¹,

et al. 2020

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Providing guidelines to health care workers during a period of rapidly evolving viral pandemic infections is not an easy task, but it is extremely necessary in order to coordinate appropriate action so that all patients will get the best possible care given the circumstances they are in. With these International Society of Infectious Disease in Obstetrics and Gynecology (ISIDOG) guidelines we aim to provide detailed information on how to diagnose and manage pregnant women living in a pandemic of COVID-19. Pregnant women need to be considered as a high-risk population for COVID-19 infection, and if suspected or proven to be infected with the virus, they require special care in order to improve their survival rate and the well-being of their babies. Both protection of healthcare workers in such specific care situations and maximal protection of mother and child are envisioned.

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Section: Pregnancy Complications: What Are the Risks For The Pregnancy?mentioning

confidence: 99%

ISIDOG Recommendations Concerning COVID-19 and Pregnancy

Donders¹,

et al. 2020

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“…Some children born from complicated pregnancies have already been suffering from severe diseases, such as asthma [31,32], pulmonary hypertension [33][34][35], diabetes mellitus [36], cardiorenal metabolic syndrome [37], chronic kidney diseases [38,39], cardiovascular diseases [40], ophthalmic disorders [41], neurodevelopmental and neuropsychiatric disorders [42][43][44][45][46][47][48][49][50][51], most likely as a result of abnormal fetal programming.…”

Section: Introductionmentioning

confidence: 99%

Association Analysis in Children Born from Normal and Complicated Pregnancies—Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects

Hromadníková

Krofta

Širc

2020

IJMS

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The goal was to assess how a history of any kind of pregnancy-related complication altered expression profile of microRNAs played a role in the pathogenesis of diabetes, cardiovascular and cerebrovascular diseases in the peripheral blood leukocytes of children at the age of 3–11 years. The prior exposure to gestational hypertension, preeclampsia, fetal growth restriction, gestational diabetes mellitus, preterm prelabor rupture of membranes or spontaneous preterm birth causes that a significant proportion of children (57.42% to 90.0% specifically) had a substantially altered microRNA expression profile, which might be the origin of a lifelong cardiovascular risk. A total of 23 out of 29 tested microRNAs were upregulated in children born from such complicated gestation. The occurrence of overweight, obesity, valve problems and heart defects even intensified upregulation of microRNAs already present in children exposed to such pregnancy complications. The occurrence of overweight/obesity (miR-92a-3p, and miR-210-3p) and valve problems or heart defects (miR-342-3p) induced microRNA upregulation in children affected with pregnancy complications. Overall, 42.86% overweight/obese children and 27.36% children with valve problems or heart defects had even higher microRNA levels than children with normal clinical findings after complicated pregnancies. In addition, the microRNA expression profile was also able to differentiate between children descending from normal gestation in relation to the occurrence of overweight and obesity. Screening on the base of the combination of 19 microRNAs identified 70.0% overweight/obese children at 90.0% specificity. In general, children after complicated pregnancies, just as children after normal pregnancies, with abnormal findings are at a higher risk of the onset of cardiovascular complications, and their dispensarization, with the aim to implement primary prevention strategies, would be beneficial.

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“…A low MCA impedance indicates redistribution of fetal cardiac output preferentially to crucial fetal organs, such as the brain, heart and adrenal glands, in response to fetal hypoxemia and/or hypercapnia [29][30][31][32] . There is abundant evidence showing that cerebral blood-flow redistribution is associated with a spectrum of adverse short-and long-term outcomes [33][34][35][36][37][38][39][40][41][42][43][44] . Moreover, in late-onset FGR, cerebral blood-flow redistribution may be the only Doppler sign to suggest placental dysfunction 19,36,45 .…”

Section: Middle Cerebral Artery Dopplermentioning

confidence: 99%