An A₂B₃ Phenotype Blood Showing Atypical Mode of Inheritance

Abstract

Taku KOMAI, M.J.A., April 12, 1965) The propositus is a 10-year-old healthy Japanese girl whose blood. was easily typed as of AB group with anti-B antibody in her serum... Further detailed examination indicated that both the antigens A and. B in her cells were weaker than those of normal AB group, while in her saliva she secreted A-and H-substances, but no B-substance. The pedigree studies revealed that there were four individuals of

Biochemical, Serological and Family Studies in Individuals with Cis AB Phenotypes

“…This phenomenon occurred in a Polish family of which two daughters had AB red cell pheno type while erythrocytes of mother and father could be classified as AB and O, respectively. Thereafter, a number of other families which had this AB phenotype and exhibited similar inheritance of A and B genes were found in Japan [16] [7], in his comment to the paper of Yamaguchi et al [16], proposed the term 'cis AB' to distinguish this phenotype from normal AB phenotypes resulting from copresence of A and B alleles. It was assumed that as a result of intragenic crossing over the ABO locus became heterogenic [1] which might result in concomitant production of both A and B synthesizing enzymes.…”

The Action of Group Bm or CisAB Sera on Group O Red Cells in the Presence of UDP-D-Galactose

“…As reported by Seyfried et al [20] and Yamaguchi et al [24][25][26], CisAB serum contains cold anti-B agglutinin as a rule. But even after absorption of this cold agglutinin with B red cells, CisAB serum could not convert O red cells into B-active cells.…”

The Donor Cross-Specificity of Human Blood Group Aand B-Synthesizing Glycosyltransferases

“…Based on the inheritance pattern, it was postulated that the ABO genes were inherited simultaneously on a single chromosome [35]. This rare phenotype was named cis-AB by the authors to distinguish it from the much more common trans-AB phenotype.…”