An 8-Year-Old Girl with a History of Stiff and Painful Joints

Raiman, Julian; D׳Aco, Kristin

doi:10.3928/00904481-20140723-05

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Skeletal deformities, such as coxa valga and genua valga, are typical, frequent, and painful abnormalities in MPS patients, but no prevalence data are available [ 61 ]. Carpal tunnel syndrome (CTS) in children is strongly suggestive of MPS or mucolipidosis [ 62 , 63 , 64 ]. Hand pain, numbness, paresthesias, and a feeling of weakness in hand grip are the principal symptoms referred by children [ 65 ].…”

Section: Epidemiology Of Painmentioning

confidence: 99%

Pain in Mucopolysaccharidoses: Analysis of the Problem and Possible Treatments

Congedi

Orzalesi²,

Pede

et al. 2018

IJMS

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Mucopolysaccharidosis (MPS) are a group of lysosomal storage disorders that are caused by the deficiency of enzymes involving in the catabolism of glycosaminoglycan (GAGs). GAGs incompletely degraded accumulate in many sites, damaging tissues and cells, leading to a variety of clinical manifestations. Many of these manifestations are painful, but few data are available in the literature concerning the prevalence, etiology, and pathogenesis of pain in children with MPS. This review, through the analysis of the data available the in literature, underscores the relevant prevalence of pain in MPSs’ children, provides the instruments to discern the etiopathogenesis of the disease and of pain, illustrates the available molecules for the management of pain and the possible advantages of non-pharmacological pain therapy in MPSs’ patients.

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Section: Epidemiology Of Painmentioning

confidence: 99%

Pain in Mucopolysaccharidoses: Analysis of the Problem and Possible Treatments

Congedi

Orzalesi²,

Pede

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

The Complexity of Pain Management in Children Affected by Mucopolysaccharidoses

Congedi

Pede

Scarpa

et al. 2017

Case Reports in Pediatrics

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Mucopolysaccharidoses (MPSs) are a group of rare, genetic lysosomal storage disorders. They are caused by deficiencies of the lysosomal enzymes involved in the degradation of glycosaminoglycans (GAGs). Pain is a common feature in mucopolysaccharidoses. However, the pathophysiology of pain in this group of diseases is still unclear and genesis of pain is multifactorial. Currently, poor data about pain management in these patients are available. Here, we present our clinical experience in complex pain management in three children with MPS.

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An 8-Year-Old Girl with a History of Stiff and Painful Joints

Cited by 2 publications

References 6 publications

Pain in Mucopolysaccharidoses: Analysis of the Problem and Possible Treatments

Pain in Mucopolysaccharidoses: Analysis of the Problem and Possible Treatments

The Complexity of Pain Management in Children Affected by Mucopolysaccharidoses

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