Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation

Chico, Lucia; Ienco, Elena Caldarazzo; Bisordi, Costanza; Gerfo, Annalisa Lo; Petrozzi, Lucia; Petrucci, Antonio; Mancuso, Michelangelo; Siciliano, Gabriele

doi:10.2174/1871527317666180720162029

Cited by 71 publications

(60 citation statements)

References 34 publications

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“…The most promising phytochemical, curcumin has a protective role in ALS too. It acts for mitochondrial biogenesis leading the AMP/PGC-1α and/or Nfr2 pathway [83]. The clinical studies show the effectiveness of curcumin for slowing down the progress of the disease.…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

“…Curcumin helps in the improvement of aerobic metabolism and oxidative stress. The antioxidative mechanism is responsible for leading the protective effect against ALS [83]. A studied phytochemical named withaferin A shows an anti-inflammatory effect by working as antagonistic of NF-κB and is found to be effective for the improved motor activity in transgenic mice model [84].…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

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Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

et al. 2020

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With the increase in the expectancy of the life span of humans, neurodegenerative diseases (NDs) have imposed a considerable burden on the family, society, and nation. In defiance of the breakthroughs in the knowledge of the pathogenesis and underlying mechanisms of various NDs, very little success has been achieved in developing effective therapies. This review draws a bead on the availability of the nutraceuticals to date for various NDs (Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, vascular cognitive impairment, Prion disease, Spinocerebellar ataxia, Spinal muscular atrophy, Frontotemporal dementia, and Pick’s disease) focusing on their various mechanisms of action in various in vivo and in vitro models of NDs. This review is distinctive in its compilation to critically review preclinical and clinical studies of the maximum phytochemicals in amelioration and prevention of almost all kinds of neurodegenerative diseases and address their possible mechanism of action. PubMed, Embase, and Cochrane Library searches were used for preclinical studies, while ClinicalTrials.gov and PubMed were searched for clinical updates. The results from preclinical studies demonstrate the efficacious effects of the phytochemicals in various NDs while clinical reports showing mixed results with promise for phytochemical use as an adjunct to the conventional treatment in various NDs. These studies together suggest that phytochemicals can significantly act upon different mechanisms of disease such as oxidative stress, inflammation, apoptotic pathways, and gene regulation. However, further clinical studies are needed that should include the appropriate biomarkers of NDs and the effect of phytochemicals on them as well as targeting the appropriate population.

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Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

et al. 2020

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“…Curcumin may improve survival in patients with ALS, especially those with bulbar involvement (Ahmadi et al, 2018). In a double-blind therapeutic trial, treatment with curcumin showed a decrease in ALS progression and a reduction of oxidative damage (Chico et al, 2018) (Table 1).…”

Section: Curcuminmentioning

confidence: 99%

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

et al. 2020

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD +) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.

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“…To our knowledge, only two studies that evaluated the exercise-induced oxidative stress remodulation in ALS have been conducted in humans (Pasquinelli et al, 2016;Chico et al, 2018). In both studies, the exercise protocol, on the forearm muscles with a myometer, consisted in several steps in which the contractile force increased incrementally at 30, 50, and 70% of the MVC, each step including 1 min of intermittent contractions (∼1/s) and 2 min of rest.…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

“…In the second study, Chico et al (2018) evaluated, over a period of 6-month trial and compared to clinical scores, the exercise-related effects, on the same redox parameters, of the oral administration of a curcumin-based compound (600 mg/day, Brainoil), a natural antioxidant nutraceutical, in ALS patients. Patients were randomized into two groups: group A (n = 24) received placebo for 3 months, then Brainoil for the following 3 months; group B (n = 18) took Brainoil for 6 months.…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Exercise-Related Oxidative Stress as Mechanism to Fight Physical Dysfunction in Neuromuscular Disorders

et al. 2020

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Neuromuscular diseases (NMDs) are a group of often severely disabling disorders characterized by dysfunction in one of the main constituents of the motor unit, the cardinal anatomic-functional structure behind force and movement production. Irrespective of the different pathogenic mechanisms specifically underlying these disease conditions genetically determined or acquired, and the related molecular pathways involved in doing that, oxidative stress has often been shown to play a relevant role within the chain of events that induce or at least modulate the clinical manifestations of these disorders. Due to such a putative relevance of the imbalance of redox status occurring in contractile machinery and/or its neural drive in NMDs, physical exercise appears as one of the most important conditions able to positively interfere along an ideal axis, going from a deranged metabolic cell homeostasis in motor unit components to the reduced motor performance profile exhibited by the patient in everyday life. If so, it comes out that it would be important to identify a proper training program, suitable for load and type of exercise that is able to improve motor performance in adaptation and response to such a homeostatic imbalance. This review therefore analyzes the role of different exercise trainings on oxidative stress mechanisms, both in healthy and in NMDs, also including preclinical studies, to elucidate at which extent these can be useful to counteract muscle impairment associated to the disease, with the final aim of improving physical functions and quality of life of NMD patients.

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Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation

Cited by 71 publications

References 34 publications

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

Exercise-Related Oxidative Stress as Mechanism to Fight Physical Dysfunction in Neuromuscular Disorders

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