Amyloidtumors of the Lung — An Immunocytomal?

Ihling, Ch.; Weirich, Gregor; Gaa, Andreas; Schaefer, Hans E.

doi:10.1016/s0344-0338(96)80006-9

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…15 Nine cases, including our two recent cases, have been reported of otherwise histologically typical pulmonary amyloidomas being associated with a monoclonal lymphoplasmacytic infiltrate. [18][19][20][21][22][23] Of these cases, age ranges from 55 to 73 with male predominance (7 of 9 cases). All cases demonstrated multifocal lesions with the exception of our new case presentation (Case 1).…”

Section: Discussionmentioning

confidence: 99%

“…Both B cell lymphoma and mucosa-associated lymphoid tissue (MALT) must be ruled out as both associations have been described in rare cases. [19][20][21][22] Diagnostic uncertainty and symptoms secondary to mass effect often prompt biopsy and surgical resection of these lesions. Transbronchial or endobronchial biopsy can sometimes facilitate analysis, however thoracoscopic wedge resection or open lung biopsy are often needed for diagnosis certainty.…”

Section: Discussionmentioning

confidence: 99%

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Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

et al. 2016

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Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain and immunoglobulin heavy chain proteins with a polyclonal lymphoplasmacystic infiltrate. Herein we present two cases of NPA of the rarely reported monoclonal (light-chain restricted) form with review of the literature and discussion of the clinical, radiographic, and histologic features of NPA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

et al. 2016

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“…2 Although the distribution of amyloid in the lungs and the association with primary disease and systemic illness have been well described, 23 coexistent lymphoma has been reported in only two previous cases. 18 19 The observation of six patients with coexistent pulmonary marginal zone lymphoma and localised amyloidosis mandates further investigation into the pathogenetic mechanisms. In addition, the presence of amyloid deposits in the lung should raise suspicion for underlying or concurrent lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis

Lim

Lacy

Kurtin

et al. 2001

Journal of Clinical Pathology

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Aim-To describe six patients with pulmonary marginal zone lymphoma in whom amyloid deposition was identified. Marginal zone lymphoma is a recently recognised type of low grade nonHodgkin's lymphoma. Methods-A computerised search was performed of all patients seen at the Mayo Clinic with a diagnosis of pulmonary amyloidosis. Six patients with pulmonary amyloidosis who had biopsy confirmed extranodal marginal zone lymphoma of mucosa associated lymphoid tissue type were identified. All were women, ranging in age from 45 to 85 years. Results-Five patients had amyloid deposition in conjunction with pulmonary marginal zone lymphoma at the time of the original diagnosis. One patient was referred for evaluation of localised pulmonary amyloidosis and was found to have coexisting pulmonary marginal zone lymphoma. Clinical presentation was limited to pulmonary symptoms (two of the six) or constitutional symptoms (two), or was asymptomatic (two). In all six cases, initial findings of nodular densities on screening chest roentgenograms led to further evaluation and eventual lobectomy; these findings included multiple pulmonary nodules (four), single nodule (one), and single nodule with diVuse bilateral interstitial infiltrates (one). Bone marrow was examined in five patients and was normal in all. Protein studies performed in four patients revealed no monoclonal protein.No patients had manifestations of systemic amyloidosis, such as renal, neurological, or cardiac involvement, at a median follow up of 50 months. Four of the six patients remain alive at a median of five years. Conclusions-Pulmonary marginal zone lymphoma may be found in association with localised amyloid deposition and should be considered in the diVerential diagnosis of localised pulmonary amyloidosis. (J Clin Pathol 2001;54:642-646)

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“…In addition to the cases with a benign course [9,10], some studies have demonstrated the coexistence of nodular pulmonary amyloidosis with low-grade pulmonary lymphomas: marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) [18,35], small-cell non-Hodgkin's lymphoma [4], and lymphoplasmacytoid lymphoma [11]. Clinically, in these cases of localized pulmonary amyloidosis, the lymphomas were restricted to the lung alone, at least in the early stages when amyloid disease was discovered.…”

Section: Introductionmentioning

confidence: 99%

Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis

et al. 2005

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Localized pulmonary amyloidosis is a rare condition whose pathogenesis is insufficiently understood. In the present study, we report a case of localized pulmonary amyloidosis associated with lung-restricted lymphoplasmacytoid lymphoma, monoclonal for immunoglobulin (Ig) G lambda (lambda). Biochemical microtechniques have been applied for extraction, purification, and characterization of amyloid proteins. Surprisingly, chemical analysis of these proteins revealed a not-previously-described case of combined deposits containing Ig fragments of gamma heavy chain (variable domain) and lambda light chain (constant domain). In view of the absence of circulating monoclonal Ig, this case supports the hypothesis that localized amyloid is formed by local plasmacytoid cells.

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Amyloidtumors of the Lung — An Immunocytomal?

Cited by 15 publications

References 34 publications

Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis

Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis

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