Amyloidosis of the Rectum Mimicking Collagenous Colitis

García-González, Rosa; Fernández, Freddy Delgado; Garijo, M. Francisca; Val-Bernal, J. Fernando

doi:10.1016/s0344-0338(98)80134-9

Cited by 46 publications

(7 citation statements)

References 14 publications

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“…Localized amyloidosis of the intestine is a rare condition that involves the duodenum, jejunum, and ileum, appendix, or colorectum. The clinicopathological features are nonspecific and therefore they can masquerade several conditions such as collagenous colitis, ischemic colitis, bowel infarction, perforation, polyps, and malignant tumors [ 11 - 13 ]. The colonoscopic features include mucosal granularity, friability, erosions, ulcerations, petechial hemorrhage, and polypoid lesions [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Localized Amyloidosis of the Intestine: A Pathologist Viewpoint

Alshehri

Hussein

2020

Gastroenterol Res

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Background: Localized amyloidosis of the intestine is a rare entity, which can clinically masquerade several conditions such as colitis, polyps, and malignant tumors. This study aims to evaluate the clinicopathological features of this entity. Methods: To evaluate the clinicopathological features of this entity, a comprehensive search of the literature (1960 to 2019) was done using the following keywords: "amyloidosis" and "small intestine" or "duodenum" or "ileum" or "jejunum" or "colon". We identified 756 studies about gastrointestinal amyloidosis. Data were examined for 27 studies about localized intestinal amyloidosis. The clinicopathological features were described. Results: The age at presentation ranged from 29 to 88 years. The male to female ratio was 3:1. The jejunum and sigmoid colon were the most commonly involved sites. Abdominal pain and intestinal obstruction (small intestine), or rectal bleeding (sigmoid region) were the most common clinical presentations. Colonoscopic findings included wall thickening, mucosal ulcerations (small intestine), and tumor-like masses (colon). Conclusions: The clinical presentations of localized intestinal amyloidosis depend on the site of the deposition of the amyloid. In most cases, amyloid deposits consisted of light chain protein.

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Section: Introductionmentioning

confidence: 99%

Primary Localized Amyloidosis of the Intestine: A Pathologist Viewpoint

Alshehri

Hussein

2020

Gastroenterol Res

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“…In contrast to ischemic and hemorrhagic bullous colitis, which are usually related with primary amyloidosis, amyloid colitis is associated with secondary amyloidosis. In all three reported cases, the type of amyloidosis proved to be AA (7,8).…”

mentioning

confidence: 73%

Amyloid colitis

KOCYIGIT¹,

Celıkbılek²,

TOKGOZ³

2011

Turk J Gastroenterol

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“…The clinical manifestations of amyloid deposit into the colon may mimic other diseases including inflammatory bowel disease, malignancy, ischemic colitis, and collagenous colitis [44][45][46][47]. Complications include colonic dilatation, pseudo-obstruction, stricture formation, rectal bleeding, submucosal hemorrhage, volvulus, infarction, and perforation [41,[48][49][50][51][52].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Clinical management of gastrointestinal amyloidosis

Isomoto¹,

Kamo²,

Chen³

et al. 2012

OJGas

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Amyloidosis is characterized by extracellular deposition of abnormal protein, consisting of primary, secondary, hemodialysis-related, hereditary, senile and localized type. Primary amyloidosis is associated with monoclonal light chains. Secondary amyloidosis is associated with inflammatory, infectious, and neoplastic diseases. Amyloid deposition in the gastrointestinal tract can manifest the symptoms including diarrhea, steatorrhea, or constipation. For diagnosis, one should obtain an immunofixation of serum or urine as well as biopsy sampling of gastrointestinal mucosa stained specifically. While most gastrointestinal complications are managed symptomatically, treatment depends upon the type of amyloidosis. Causal therapy is reserved for a select few from various subtypes of this disorder

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Amyloidosis of the Rectum Mimicking Collagenous Colitis

Cited by 46 publications

References 14 publications

Primary Localized Amyloidosis of the Intestine: A Pathologist Viewpoint

Primary Localized Amyloidosis of the Intestine: A Pathologist Viewpoint

Amyloid colitis

Clinical management of gastrointestinal amyloidosis

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