Amyloidosis of heart and liver: comparison of Tc-99m pyrophosphate and Tc-99m methylene diphosphonate for detection.

Lee, V W; Caldarone, Anthony; Falk, Rodney H.; Rubinow, Alan; Cohen, A S

doi:10.1148/radiology.148.1.6304810

Cited by 61 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…'wTc-MDP normally binds to the surface of bone mineral in areas of active bone turnover [17]. wTc pyrophosphate is also used for bone scans, and there have been reports of its uptake at sites where AL amyloid has been deposited, in visceral organs, and joints [12,13,18]. The isotope vehicles are thought to bind to the calcium present in amyloid deposits.…”

Section: Discussionmentioning

confidence: 99%

“…However, many of these patients are often unable to undergo the invasive procedures necessary to obtain specimens, and a reliable and sensitive in vivo diagnostic technique is, therefore, required to make the diagnosis. Encouraged by reports in patients with AL amyloid, of the uptake of "Tc-labelled methylene diphosphonate ("Tc-MDP) and "Tc-Iabelled pyrophosphate [11][12][13], we investigated the use of bonescans in the diagnosis of joint disease due to pr microglobulin-associated amyloid.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Technetium-99-Labelled Methylene Diphosphonate Uptake Scans in Patients with Dialysis Arthropathy

Sethi

Morgan²,

Brown³

et al. 1990

Nephron

View full text Add to dashboard Cite

Patients on long-term haemodialysis suffer from dialysis arthropathy due to the deposition of dialysis amyloid. We investigated the use of ⁹⁹Tc-labelled methylene diphosphonate bone scans in 17 patients as a possible in vivo diagnostic technique. In most clinically affected joints, with the exception of shoulders and hands, there was increased radioisotope uptake consistent with uptake by periarticular bone. In addition, we describe intense soft-tissue uptake around some clinically affected large joints. In contrast, control groups of patients on haemodialysis without arthropathy and patients without renal failure did not have increased uptake. A semi-quantitative scale of uptake was devised, and the following correlations were significant: pain perception and isotope uptake score in the ankles and feet, and the number of radiological lesions and isotope uptake scores in the wrists and knees. The following sites where the radioisotope might bind in the affected joints are proposed: amyloid deposits, areas of soft-tissue calcification, or areas of increased bone turnover. It is concluded that whereas the scanning technique cannot make a definite diagnosis of amyloid and, therefore, cannot be expected to supersede histological diagnosis, it is a useful adjuvant investigation, of particular importance in those patients unable or unwilling to undergo biopsy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Technetium-99-Labelled Methylene Diphosphonate Uptake Scans in Patients with Dialysis Arthropathy

Sethi

Morgan²,

Brown³

et al. 1990

Nephron

View full text Add to dashboard Cite

show abstract

“…All seven patients had abnormal cardiac and/or hepatic 99m Tc-PYP uptake, compared to only four patients who were injected with 99m Tc-MDP. 99m Tc-PYP was found to be a better scanning agent for softtissue amyloidosis and for cardiac localization of amyloid [54]. A year later, Eriksson et al reported less convincing results for 99m Tc-PYP.…”

Section: Amyloid Deposits 99m Tc-aprotininmentioning

confidence: 99%

Nuclear imaging in cardiac amyloidosis

Glaudemans

Slart

Zeebregts

et al. 2009

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Amyloidosis is a disease characterized by depositions of amyloid in organs and tissues. It can be localized (in just one organ) or systemic. Cardiac amyloidosis is a debilitating disease and can lead to arrhythmias, deterioration of heart function and even sudden death. We reviewed PubMed/Medline, without time constraints, on the different nuclear imaging modalities that are used to visualize myocardial amyloid involvement. Several SPECT tracers have been used for this purpose. The results with these tracers in the evaluation of myocardial amyloidosis and their mechanisms of action are described. Most clinical evidence was found for the use of 123 I-MIBG. Myocardial defects in MIBG activity seem to correlate well with impaired cardiac sympathetic nerve endings due to amyloid deposits. 123 I-MIBG is an attractive option for objective evaluation of cardiac sympathetic level and may play an important role in the indirect measurement of the effect of amyloid myocardial infiltration. Other, less sensitive, options are 99m Tc-aprotinin for imaging amyloid deposits and perhaps 99m Tc-labelled phosphate derivatives, especially in the differential diagnosis of the aetiology of cardiac amyloidosis. PET tracers, despite the advantage of absolute quantification and higher resolution, are not yet well evaluated for the study of cardiac amyloidosis. Because of these advantages, there is still the need for further research in this field.

show abstract

“…[2][3][4][5] Pulmonary amyloidosis is classified into tracheobronchial and parenchymal types according to the site of the amyloid deposition. 6 We describe a patient with tracheobronchial amyloidosis, in whom SPECT demonstrated localized 99 mTc-HMDP deposition.…”

Section: Introductionmentioning

confidence: 99%

Demonstration of primary tracheobronchial amyloidosis by99mTc-HMDP bone SPECT

et al. 1993

View full text Add to dashboard Cite

A case of primary tracheobronchial amyloidosis is reported. A 61-year-old man presented with a 2-year history of intermittent hemoptysis. Chest X-ray and CT scanning showed tracheobronchial thickening. Bronchoscopic examination revealed diffuse tracheobronchial narrowing, and tracheobronchial biopsy detected amyloid deposits. Both 99mTc-HMDP planar and SPECT images were obtained in this patient. Coronal SPECT images revealed more precisely that the activity was not in the thoracic cage but in the bilateral hilar region. Localization of the amyloid deposits could be better determined on SPECT images than on planar images.

show abstract

Amyloidosis of heart and liver: comparison of Tc-99m pyrophosphate and Tc-99m methylene diphosphonate for detection.

Cited by 61 publications

References 0 publications

Technetium-99-Labelled Methylene Diphosphonate Uptake Scans in Patients with Dialysis Arthropathy

Technetium-99-Labelled Methylene Diphosphonate Uptake Scans in Patients with Dialysis Arthropathy

Nuclear imaging in cardiac amyloidosis

Demonstration of primary tracheobronchial amyloidosis by99mTc-HMDP bone SPECT

Contact Info

Product

Resources

About