Amyloidosis in Guinea-pigs immunized with Sperm and Adjuvant

Plank, Stephen J.; Hunt, Ronald D.; Cohen, Alan S.

doi:10.1038/2141368a0

Cited by 6 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sodium alginate may be more suitable than Freund's as an adjuvant in studies on induced infertility, because Freund's can cause pathological changes in many organs (Ram, Glenner & DeLellis, 1968;Plank, Hunt & Cohen, 1967;Boss, 1965) and affect the oestrous cycle (Battisto, Pinto & Joseph, 1967).…”

Section: Insemination Period Groupmentioning

confidence: 99%

Iso-Antibody Formation Against Rabbit Spermatozoa and Its Effect on Fertility

Bell¹

1969

Reproduction

View full text Add to dashboard Cite

Section: Insemination Period Groupmentioning

confidence: 99%

Iso-Antibody Formation Against Rabbit Spermatozoa and Its Effect on Fertility

Bell¹

1969

Reproduction

View full text Add to dashboard Cite

“…Although there were significant numbers of embryonic deaths, the major effect was a decreased fertilization rate. One suspects from recent reports of pathological disorders induced by Freund's complete adjuvant (Boss, 1965;Plank, Hunt & Cohen, 1967;Ram, Glenner & DeLellis, 1968) (Bell & Wood, 1968) (Bell, 1969a) (Brown et al, 1967;Toullet 8c Voisin, 1969). Moreover, the ultimate factor may be the local concentration of specific antibody at the site of fertilization (or within the reproductive tract) and need not correlate with humoral levels.…”

Section: Immunological Assaysmentioning

confidence: 99%

Reduction of Fertility in Female Mice Iso-Immunized With a Sub-Cellular Sperm Fraction

Bell¹,

McLaren²

1970

Reproduction

View full text Add to dashboard Cite

show abstract

Ultrastructural studies of renal peritubular amyloid experimentally induced in guinea pigs. II. Tubular epithelial cells

Cohen

Shirahama

1971

Arthritis & Rheumatism

View full text Add to dashboard Cite

The ultrastructure of cells of the renal tubule and its relationship to subepithelial amyloid deposits were studied in experimentally induced amyloidosis in guinea pigs. Amyloid fibrils were demarcated primarily between the epithelial cell and its basement membrane. Basal plasmalemmal infoldings were diminished whenever the cell abutted amyloid. Pocket-like plasmalemmal invaginations, associated with tufts of well-oriented amyloid fibrils, were found occasionally. lntracellular membrane-bound amyloid fibrils, fibrils i n the extracellular space between two epithelial plasma membranes, and fibrils surrounded by basement membrane were also seen on rare occasions. These findings are discussed in relation to clinical features of renal amyloidosis.In a previous communication (1) we surveyed casein-induced renal amyloidosis in guinea pigs by light and electron microscopy. I n brief, the renal amyloid was peritu- bular and classified as subepithelial, pericapillary or interstitial, depending upon the site of the lesion on electron microscopic study. A major site of deposition of amyloid fibrils was between the epithelial cell and the basement membrane, where deposits were oriented or polarized towards the adjacent capillary. Changes in the infoldings of the basal plasma membrane of the renal tubule cell were also observed. This communication describes in greater detail the ultrastructural features of renal tubule cells and their relation to the subepithelial amyloid deposits.

show abstract

Amyloidosis in Guinea-pigs immunized with Sperm and Adjuvant

Cited by 6 publications

References 4 publications

Iso-Antibody Formation Against Rabbit Spermatozoa and Its Effect on Fertility

Iso-Antibody Formation Against Rabbit Spermatozoa and Its Effect on Fertility

Reduction of Fertility in Female Mice Iso-Immunized With a Sub-Cellular Sperm Fraction

Ultrastructural studies of renal peritubular amyloid experimentally induced in guinea pigs. II. Tubular epithelial cells

Contact Info

Product

Resources

About