Amyloidosis in children

The Changing Pattern of Renal Amyloidosis in Indian Subcontinent: Two Decades of Experience from a Single Center

“…In contrast, in developed countries, this changing pattern had already been prevailing since decades ago, and chronic inflammations have been the most common cause of renal amyloidosis. 10,[22][23][24] The decline in the incidence of amyloidosis secondary to chronic infections had been largely attributed to the introduction of effective anti-tuberculosis and anti-leprosy chemotherapy and the improvement of standard of living of our population. However, after the subgroup analysis, tuberculosis still remains as the most common etiology in both the groups (35.29% and 24.1% in 1990s and 2000s, respectively), while the incidence of leprosy (23% in 1990s vs. 3.4% in 2000s) was markedly decreased.…”

“…In other Indian studies, tuberculosis accounted for 55-79% of renal amyloidosis, but most of the studies were conducted in between1960s and1990s. [3][4][5]24 On other hand, in developed countries, tuberculosis accounted for 50-80% of secondary amyloidosis in 1940s and 1950s. [25][26][27] We observed that chronic inflammatory causes (RA, AS, etc.)…”

Synthesis of amide‐linked benzazolyl isoxazoles adopting green methods and evaluation as antimicrobials

“…Though there are different procedures for the preparation of isoxazoles from isoxazolines, using I 2 in DMSO has gained considerable importance. Thus N-(2-(benzo [d]oxazol-2ylamino)-2-oxoethyl)-3,5-diphenylisoxazole-4-carboxamide (7), [d]imidazol-2-yl)amino)-2-oxoethyl)-3,5-diphenylisoxazole-4-carboxamide (9) were synthesized by the reaction of 4, 5, and 6 with iodine in dimethyl sulfoxide, respectively (Scheme 1). In fact, iodine abstracts the hydride ion at fourth carbon of isoxazole followed and elimination of proton.…”

“…[2] Many known drugs such as sulfisoxazole, [3] sulfamethaxazole, oxacillin, cloxacillin, dicloxacillin, [4] isocarboxazide, muscimol, valdecoxib, and leflunomide are constituents of isoxazole moiety. [5,6] Isoxazole and its derivatives exhibit antibacterial, [7] antiviral, [8] anticancer, [9] antiplatelet, anti-inflammatory, [10] analgesic, [11] and anticonvulsant activities. On the other hand, benzoxazoles, benzothiazoles, and benzimidazoles possess a wide range of biological activities including antioxidant, anti-inflammatory, analgesic, antituberculosis, antiviral, and antimicrobial.…”

Amyloidosis in a Child with Leucocyte Adhesion Deficiency Type-1: An Unusual Association

“…Only systemic AA amyloidosis occurs in children secondary to chronic inflammatory conditions like juvenile rheumatoid arthritis, familial Mediterranean fever, tuberculosis etc. [8,9]. The most common clinical presentation of AA amyloidosis is renal dysfunction as was seen in the present case, ranging from proteinuria to nephrotic syndrome and renal failure [8].…”