Amyloidosis Cutis Dyschromica, A Rare Subtype of Primary Cutaneous Amyloidosis

Amyloidosis Cutis Dyschromica in a 16-Year-Old Filipino Girl: A Case Report

“…Histiocytes or fibroblasts phagocytose the apoptotic keratinocytes. As a result, cytokeratins of the lysed keratinocytes give rise to the amyloid material, and are then deposited in the skin [ 3 , 4 , 7 , 8 ]. In these ACD cases, Yang and McGrath’s groups have consistently reported glycoprotein non-metastatic melanoma protein B (GPNMB) gene mutations [ 9 , 10 ].…”

“…ACD is characterized by the presence of hyperpigmented, hypopigmented or depigmented macules of varying sizes, which can present in generalized fashion [ 1 , 2 ]. It is associated with no or little pruritus, prepubertal onset, and focal amyloid deposition in the papillary dermis [ 3 ].…”