Amyloidosis and Bleeding: Pathophysiology, Diagnosis, and Therapy

Sucker, Christoph; Hetzel, Gerd R.; Grabensee, B; Stockschlaeder, Marcus; Scharf, R

doi:10.1053/j.ajkd.2006.03.036

Cited by 129 publications

(98 citation statements)

References 84 publications

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“…However, organ biopsy carries a significant risk of hemorrhagic complications. In systemic AL amyloidosis patients, the hemorrhagic risk may be increased by the frequent presence of coagulation abnormalities, such as acquired factor X deficiency [54], and infiltration of vessel walls by amyloid [55]. However, the outcome of a large series of renal biopsies in patients with systemic amyloidosis did not show increased bleeding risk [56].…”

Section: Detection Of Amyloid Deposits In Tissuesmentioning

confidence: 91%

Biochemical markers in early diagnosis and management of systemic amyloidoses

Lavatelli

Albertini

Fonzo

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.

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Section: Detection Of Amyloid Deposits In Tissuesmentioning

confidence: 91%

Biochemical markers in early diagnosis and management of systemic amyloidoses

Lavatelli

Albertini

Fonzo

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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show abstract

“…Acquired factor deficiencies have been reported in patents with AL-amyloidosis and less so with other types of amyloidosis [12]. In patients with amyloidosis, factor X deficiency is the most commonly reported factor deficiency [5], with a frequency between 7% [7] and 14% [8].…”

Section: Commentarymentioning

confidence: 99%

Coagulopathy in a patient with nephrotic syndrome

et al. 2010

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“…Petecchiae, purpura in periorbital and facial areas ecchymosis and bleeding tendencies are common clinical features and severe hemorrhages may contribute to worsening the clinical course and lead to death. Increased fragility of blood vessels and impaired vasoconstriction, caused by deposition of insoluble fiber, are frequent causes of bleeding (9,10). Acquired coagulation factor deficiency, most commonly factor X, is a unique feature of AL amyloidosis.…”

Section: Clotting Alterationsmentioning

confidence: 99%