Amyloidosis

A case of systemic amyloidosis showing papular/nodular lesions due to Waldenström's macroglobulinemia

“…AL amyloidosis affects various organs/tissues, including the kidneys, heart, nerves, and skin 3 . Cutaneous manifestations are dependent on the histological area where amyloid protein deposits; previous literature reported that protein deposition in vessel walls, folliculosebaceous units, and the epidermis/dermis causes purpura, alopecia, and papules/nodules, respectively 4 .…”

A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance

“…It is also most commonly associated with GI manifestations [ 1 - 4 ]. In Western countries, AL amyloidosis has an incidence of one case per 100,000 person-years [ 5 ]. In this disease, amyloid proteins invade mucosal or neuromuscular tissues, leading to fragile blood vessels, decreased gut wall compliance, and symptoms resembling fibrotic liver disease [ 1 , 3 ].…”

“…Treatment typically involves supportive care, including volume resuscitation, dietary modifications, pro-kinetic or antiemetic medications, surgery, and treatment of underlying malignancy [ 1 - 3 ]. For AL amyloidosis, as it is commonly caused by plasma cell dyscrasias, autologous stem cell transplant or chemotherapy with a combination of melphalan, bortezomib, and dexamethasone is associated with increased survival [ 1 , 2 , 5 ]. The prognosis of patients with amyloidosis and GI involvement appears worse than those without GI involvement [ 1 ].…”