Amyloidoses of the Kidney and Genitourinary Tract

Histological and proteomic characterization of musculoskeletal amyloidomas

“…In general, proteomics showed concordance with IHC, and elucidated the nature of the protein deposit in the doubt IHC cases 1 and 4. Several proteins known to deposit within the amyloid plaque were also among the thirty most abundant proteins, including the "amyloid signature" [19,24,29] proteins apolipoprotein E (APOE), apolipoprotein A-IV (APOA4) and serum amyloid-P component (APSC). APOA1 is another amyloid precursor [19]; APOA1, together with APOA4, APOE and APSC, have been detected in many cases of λ light chain amyloidomas [30].…”