Amyloidomas of soft parts: Diagnosis by fine‐needle aspiration

Abstract

A tumoral mass of amyloid (amyloidoma) arising in the soft tissues of the distal extremities is exceedingly unusual, and applying the fine-needle aspiration (FNA) biopsy technique to specifically diagnose this condition is even more infrequent. Herein, we report an example of two separate amyloidomas arising in the right calf of an otherwise asymptomatic elderly man who was referred to the sarcoma clinic because these masses clinically and radiographically simulated a malignant neoplasm. The fine-needle aspirate yielded amorphous, acellular, dense blue material on Romanowsky-stained smears and smudgy acellular cyanophilic material on Papanicolaou-stained smears. The aspirate procured cell-block contained hyalinized eosinophilic acellular material on H&E stain that was Congo-red positive and displayed yellow-green birefringence with polarization. Unlike prior assertions to the contrary, a diagnosis of amyloidoma is possible using FNA cytopathology even in patients without a known underlying amyloidogenic disorder.

Comparison of transbronchial needle aspiration with and without ultrasound guidance for diagnosing benign lymph node adenopathy

“…In addition to sampling techniques, preparation technique is also a pronounced determinant for diagnostic performance. Accumulated evidence shows that conventional cytological evaluation is capable to provide diagnostic clues in non-granulomatous diseases, such as amyloidosis, necrotizing lymphadenitis [37,38]. On the other hand, cytology is a more potent diagnostic tool for granulomatous disease.…”

Cytological diagnosis of amyloidosis presenting as a supraclavicular swelling

“…Only a handful of case reports describe amyloidosis in the cervical region. Nevertheless, the literature on its cytological diagnosis is sparse …”

Pancreatic amyloidoma associated with elevated CA19‐9: A case diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration biopsy

“…Amyloidoma, also called amyloid tumor, is a nodular amyloid deposit. It is the least common presentation of amyloidosis and a well‐known mimicker for neoplasm . Amyloidosis is often associated with plasma cell dyscrasias (such as multiple myeloma, Waldenstrom macroglobulinemia, monoclonal gammopathy of undetermined significance (MGUS), and rarely B cell type Non‐Hodgkin lymphoma) and chronic inflammatory diseases (such as rheumatoid arthritis, Sjögren syndrome, and tuberculosis) .…”