Amyloidoma, an Unusual Cause of Fracture

Abstract

We report a case of a spontaneous hip fracture in a context of dysglobulinemia. The bone histologic examination found amyloidoma. Amyloidoma is an overload pathology and an unusual cause of fracture. In most of the cases, it is associated with myeloma and the difference between bone invasion of myeloma and amyloidoma in an osteolytic radiographic picture is not easy but is of importance because prognosis and treatment may be totally different. Thus, in the context of dysglobulinemia, one must keep in mind that spontaneous bone fracture may be due to amyloidoma with another prognosis.

Primary osseous amyloidoma - Report of two cases with review of the literature

“…This tumoral form of amyloidosis characterized by the localized deposition of amyloid is a diagnostic challenge. Review of the literature reveals the overwhelming majority of skeletal amyloidoma occur in axial skeleton loci such as the spine, skull, and ribs [11]. Of the two amyloidoma cases we reported, one occurred in the axial and the other in the appendiceal skeleton.…”

“…Most reported cases of primary osseousamyloidoma are localized in the axial skeleton, including eightpublished occurrences in the skull [1][2][3][4][5][6][7][8]. Appendicular involvement is far less common with only two cases reported in the humerus [9,10] and two in the femur [11,12]. We report two cases of isolated osseousamyloidomas: One in the anterior skull base and the other in the appendiceal skeleton.…”

Amyloidosis of the Femoral Neck: An Unusual Cause of Pathologic Fracture

“…reported a case of a pathologic femoral neck fracture in an 87-year-old male who had elevated kappa AL monoclonal plasmacytes and positive Bence Jones proteinuria [ 6 ]. At the time of arthroplasty, histologic analysis of his femoral head revealed multifocal amyloid deposits, with osteolysis and a pseudotumoral aspect (amyloidoma) [ 6 ]. He also sustained a contralateral pathologic femoral neck fracture 6 months later secondary to amyloidosis.…”

Amyloidoma of Stomach: A Case Report

“…They have been reported in many sites including the brain, dura, lung, stomach, small bowel, extremities, spine, skin, soft tissue, lymph node, and bone. Unusual presentations of amyloidomas include an abdominal wall mass presenting as an abscess [4], amyloidoma secondary to insulin injection [5], amyloidoma presenting as a fracture [6] and with spinal cord compression [7]. Treatment is conservative resection of the mass.…”