Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder

Elias, Alby; Cummins, Tia L.; Lamb, Fiona; Tyrrell, Regan; Doré, Vincent; Williams, Rob; Rosenfeld, Jeffrey V.; Hopwood, Malcolm; Villemagne, Victor L.; Rowe, Christopher C.

doi:10.3233/jad-190913

Cited by 11 publications

(8 citation statements)

References 40 publications

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“…Veterans with PTSD did not differ in Aβ and tau PET SUVR, or MRI volumes from those with no PTSD, despite having a lower Montréal Cognitive Assessment score. 34 Self-reported TBI with loss of consciousness was not associated with neuritic plaques or neurofibrillary tangles at autopsy in a pooled dataset from the Religious Orders Study (ROS), The Memory and Aging Project (MAP), and the Adult Changes in Thought (ACT) cohorts or in the National Alzheimer's Coordinating Center (NACC) cohort. 35 A history of self-reported mild TBI (mTBI) in 134 CU elders was not significantly associated with cortical Aβ burden or accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…However, in contrast to studies based on clinically diagnosed AD dementia, neither TBI nor PTSD were associated with AD biomarkers of Aβ, tau, and neurodegeneration, or with WMH, a finding consistent with other biomarker or neuropathological studies. 34,35,58 This information raises questions about alternative mechanisms underlying cognitive symptoms and AD diagnosis in these patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

Weiner

Harvey

Landau

et al. 2022

Alzheimer's & Dementia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

Weiner

Harvey

Landau

et al. 2022

Alzheimer's & Dementia

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“…After examining demographic, medical, and psychiatric covariates, results from a series of hierarchical linear regressions showed that only APOE had significant association with 18 F-Florbetaben SUVR. We have previously reported that PTSD was not associated with PET findings in this AIBL-VETS cohort 58 . A T-test on 18 F-Florbetaben SUVR showed no difference between TBI and NC (Cohen's d=0.31, p=0.2), despite the larger number of APOE4 carriers in the TBI group.…”

Section: Positron Emission Tomographymentioning

confidence: 52%

Tau, β-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study

Doré

Cummins

Feizpour

et al. 2022

Preprint

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Traumatic Brain Injury (TBI) is common amongst military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer′s disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 NIA–AA research framework, by measuring tau, β–amyloid and glucose metabolism using positron emission tomography (PET) in veterans with service–related TBI. Seventy male Vietnam war veterans — 40 with TBI (aged 68.0±2.5 years) and 30 controls (aged 70.1±5.3 years) — with no prior diagnosis of dementia or mild cognitive impairment underwent β–amyloid (18F–Florbetaben), tau (18F–Flortaucipir) and 18F–FDG PET. The TBI cohort included 15 participants with mild, 16 with moderate, and 9 with severe injury. β–amyloid level was calculated using the Centiloid (CL) method and tau was measured by Standardized Uptake Value Ratios (SUVR) using the cerebellar cortex as reference region. Analyses were adjusted for age and APOE–e4. The findings were validated in an independent cohort from the ADNI–DOD study. There were no significant nor trending differences in β–amyloid or tau levels or 18F–FDG uptake between the TBI and control groups before and after controlling for covariates. The β–amyloid and tau findings were replicated in the ADNI–DOD validation cohort and persisted when the AIBL–VETS and ADNI–DOD cohorts were combined (114 TBI vs 87 controls in total). These findings suggest that TBI is not associated with the later life accumulation of the neuropathological markers of AD.

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“…The U.S. based Alzheimer's Disease Neuroimaging Initiative (ADNI), and Australian Imaging Biomarkers and Lifestyle study of aging (AIBL) used PET imaging to estimate the uptake of radioactive tracers that bind to b-amyloid and tau in Vietnam veterans with and without PTSD. 12,14 The uptake of these tracers represents a proxy measure of amyloid and tau burden. In contrast to the epidemiological studies, these studies did not lend credence to the hypothesis of an increased risk of Alzheimer's disease pathology in PTSD, as suggested by previous structural neuroimaging studies.…”

Section: Biomarkers Of Alzheimer's Disease In Posttraumatic Stress Disordermentioning

confidence: 99%

“…10,11 Subsequent human studies with comprehensive measurements, including an array of biomarkers of AD contributed to this growing area of research. [12][13][14] This paper reviews the risk of dementia in PTSD in the light of the latest research findings. This review was conducted based on articles published on MEDLINE, EMBASE, and SCOPUS from January 1990 to December 2019.…”

Section: Introductionmentioning

confidence: 99%

Risk of Dementia in Posttraumatic Stress Disorder

Elias

Rowe

Hopwood

2020

J Geriatr Psychiatry Neurol

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Several studies have investigated the risk of dementia in posttraumatic stress disorder (PTSD) using a varying methodology. Epidemiological studies have found an increased risk of dementia with PTSD in Vietnam veterans as well as the general population. Laboratory studies reported the accelerated formation of β-amyloid and tau, which represent the primary pathology of Alzheimer’s dementia in animal models of PTSD. These investigations were conducted against a background of cognitive impairment and atrophy of the hippocampus and certain cortical areas in patients with PTSD. Very few studies have investigated the pathological basis in humans for the reported association of PTSD with dementia. This important gap in the literature has recently been partly addressed by very few studies that estimated the burden of β-amyloid and tau. The PET studies did not show an association between PTSD and the specific pathology of Alzheimer’s disease or signs of neurodegenerative diseases underlying other dementia syndromes. Another study demonstrated decreased plasma β-amyloid load and increased plasma β-amyloid 42/40 ratio in PTSD without PET evaluation. While PTSD is associated with an increased risk of dementia syndrome in general, there is no convincing evidence that it causes or accelerates the pathology of Alzheimer’s disease, which causes the most common type of dementia. Factors that may account for the association between PTSD and a clinical diagnosis of dementia are discussed in this review.

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Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder

Cited by 11 publications

References 40 publications

Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

Tau, β-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study

Risk of Dementia in Posttraumatic Stress Disorder

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